Figures & data
Figure 1 c-MET/HGF pathway.
Abbreviations: HGF, hepatocyte growth factor; PI3K, phosphoinositide 3-kinase; mTOR, mammalian target of rapamycin; Gab1; GRB-associated binding protein 1; STAT3, signal transducer and activator of transcription 3; SRC, sarcoma; Grb2, growth factor receptor-bound protein 2; SOS, son of sevenless; FAK, focal adhesion kinase-1; Pxn, paxillin; RAS, rat sarcoma; RAF, rapidly accelerated fibrosarcoma; MEK 1/2, MAPK/ERK kinase; ERK, extracellular signal regulated kinase.
Figure 2 Future possible study designs for ficlatuzumab clinical development.
Abbreviations: NSCLC, non-small cell lung cancer; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; MET, mesenchymal-epithelial transition receptor; HGF, hepatocyte growth factor; CT, chemotherapy.
