Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010

Figures & data

Table 1 Cross-reactivity of intravenous immunoglobulins to the influenza H2N2 virus

IVIG	H2N2 virus
	Okuda/1957		Izumi/5/1965		Kaizuka/2/1965
	HI	VN50	HI	VN50	HI	VN50
1993JP, Lot A	32	160	64	1280	64	1280
1993US, Lot B	64	320	128	5120	128	2560
1999JP-A, Lot C	32	160	64	1280	64	1280
1999JP-B, Lot D	32	80	64	1280	64	1280
1999JP-C, Lot E	32	160	64	1280	64	1280
1999JP-D, Lot F	32	160	64	1280	64	1280
1999US, Lot G	64	320	128	5120	128	2560
2000JP, Lot H	32	160	64	1280	64	1280
2003JP, Lot I	32	80	64	1280	64	1280
2006JP, Lot J	32	160	64	1280	64	1280
2007JP, Lot K	32	160	64	1280	64	1280
2008JP, Lot L	32	160	64	1280	64	1280
2009JP, Lot M	32	80	64	1280	64	1280
2010JP, Lot N	32	80	64	1280	64	1280

Abbreviations: HI, hemagglutination inhibition titer; IVIG, intravenous immunoglobulin; JP, Japan; US, United States; VN₅₀, virus neutralization titer giving 50% inhibition of infectivity.