Antidrug antibodies against TNF-blocking agents: correlations between disease activity, hypersensitivity reactions, and different classes of immunoglobulins

Figures & data

Table 1 Characteristics of patients at baseline

	Infliximab 32 patients	Adalimumab 39 patients	Etanercept 58 patients
Age (years)	52.3±12.2	53.6±11.8	54.5±12.9
Disease duration	5.3±2.8	5.5±3.1	5.8±2.9
Rheumatoid factor positivity	76%	78%	75%
APCA positivity	81%	79%	78%
ESR, mm	54.3±8.4	55.7±7.2	53.5±6.7
CRP, mg/dL	3.2±1.7	3.4±1.5	3.7±1.4
DAS28	5.46±2.1	5.43±1.9	5.38±1.8
Corticosteroids dose, mg/day	6.1±1.2	6.4±1.1	6.3±1.2
Methotrexat dose, mg/week	12.5±2.2	12.1±2.1	11.9±2.4

Abbreviations: APCA, anti-citrullinated peptide/protein antibody; ESR, erythrocyte-sedimentation rate; CRP, C-reactive protein; DAS, Disease Activity Score.

Figure 1 Scatter plot of specific IgG₄ antibodies versus DAS28.

Abbreviation: DAS, Disease Activity Score.

Figure 2 IgG₄ specific antibodies against three different TNF blocking agents and DAS28.

Abbreviation: DAS, Disease Activity Score.

Figure 3 Correlation between IgG₄ specific antibodies, adverse effects and DAS28.

Abbreviations: DAS, Disease Activity Score; RA, rheumatoid arthrirtis.

Figure S1 Power calculations.

Notes: Power calculation reporting power (1-beta) vs sample size (number of pairs) under the assumption of a correlation coefficient ranging from 0.4 to 0.6 (moderate weak to moderate strong) with a null correlation of 0.1 and 0.05 for the left and the right panels respectively.