The effect of oral clindamycin and rifampicin combination therapy in patients with hidradenitis suppurativa in Singapore

Figures & data

Table 1 Demographics of patients, previous treatments, response and side effects of combination therapy

Case number	Age (years)	Gender	Duration of disease (years)	Affected area(s)	Prior therapy	Physician clinical assessment	Pretreatment PGA score	Posttreatment PGA score	Reported side effects
1	18	Male	2	Axilla, neck	Doxycycline, topical clindamycin	Improved	Nil	Nil	Nil
2	18	Male	4	Perineal	Doxycycline, erythromycin, isotretinoin, minocycline	Improved	Nil	Nil	Nil
3	19	Male	9	Perineal	Bactrim, cephalexin, doxycycline, erythromycin, isotretinoin, minocycline	Improved	2.75	1.50	Nil
4	20	Male	6	Perineal, axilla	Augmentin, topical clindamycin	Nonresponder	Nil	Nil	Nil
5	21	Male	13	Perineal, axilla	Doxycycline, topical clindamycin	Improved	2.67	1.00	Nil
6	21	Male	3	Perineal, axilla, neck	Nil	Improved	1.75	2.00	Nil
7	21	Male	3	Perineal, back	Defaulted	Defaulted	Nil	Nil	Nil
8	22	Male	5	Perineal	Isotretinoin, minocycline, topical clindamycin	Improved	Nil	Nil	Nil
9	48	Male	20	Perineal, axilla	Augmentin, acitretin. ciprofloxacin, clindamycin, ceftriaxone, isotretinoin, infliximab	Nonresponder	3.13	3.00	Nil
10	27	Female	7	Perineal, axilla	Doxycycline, isotretinoin	Nonresponder	Nil	Nil	Nausea, vomiting
11	35	Female	2	Perineal, axilla	Nil	Improved	Nil	Nil	Nil

Abbreviation: PGA, Hidradenitis Suppurativa Physician Global Assessment.

Table 2 Summarized data of the available studies on rifampicin–clindamycin in HS

Reference	Number of patients	Treatment modalities	Assessment of the severity of HS	Number of patients with improvement	Number of patients with side effects
Bettoli et al^Citation1	23	Rifampicin 600 mg and clindamycin 600 mg for 10 weeks	Sartorius Number of exacerbations	17/20 (85%)	3 (13%)
Gener et al^Citation2	116	Rifampicin 600 mg and clindamycin 600 mg for 10 weeks	Sartorius Hurley Skindex-France questionnaire HS Patient Global Assessment	60/70 (86%)	10 (14%)
Mendonça and Griffiths^Citation3	14	Rifampicin 600 mg and clindamycin 600 mg for 10 weeks	No specific score	10/14 (71%)	4 (29%)
van der Zee et al^Citation4	34	Rifampicin and clindamycin different dosages and duration	Hurley Investigator total assessment	28/34 (82%)	13 (38%)
Present study	11	Rifampicin 600 mg and clindamycin 600 mg 10 weeks	HS Physician Global Assessment	7/11 (63.6%)	1 (9.1%)

Abbreviation: HS, hidradenitis suppurativa.

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