The relationship between mitotic rate and depth of invasion in biopsies of malignant melanoma

Figures & data

Table 1 Comparison of average mitotic activity at different stages of T-classification and different levels of Clark and Breslow in patients with malignant melanoma

T-stage	Number of cases (mean of mitosis ± SD)	Clark’s Level of invasion	Number of cases (mean of mitosis ± SD)	Breslow Level	Number of cases (mean of mitosis ± SD)
T1	12 (0.08 ±0.28)	I	4 (0.00±0.00)	1	8 (0.00 ±0.00)
T2	10 (1.00 ±0.66)	II	7 (0.00±0.00)	2	9 (0.56 ±0.52)
T3	12 (2.50 ±0.52)	III	9 (0.89±0.60)	3	7 (1.57 ±0.97)
T4	16 (3.50 ±0.63)	IV	18 (2.61±0.77)	4	5 (2.40 ±0.54)
P-value	<0.001	V	12 (3.50±0.67)	5	21 (3.29 ±0.71)
Total	50 (1.94 ±1.47)	P-value	<0.001	P-value	<0.001

Table 2 Comparison of different levels of mitosis at different stages of T-classification, different levels of Clark, and different levels of Breslow in patients with malignant melanoma

T-stage	Mitotic rate			Clark’s level	Mitotic rate			Breslow level	Mitotic rate
	0–1 Mitoses	2–3 Mitoses	>4 Mitoses		0–1 Mitoses	2–3 Mitoses	>4 Mitoses		0–1 Mitoses	2–3 Mitoses	>4 Mitoses
	n (%)				n (%)				n (%)
T1	12 (60)	0 (0)	0 (0)	I	4 (20)	0 (0)	0 (0)	1	8 (40)	0 (0)	0 (0)
T2	8 (40)	2 (9.5)	0 (0)	II	7 (35)	0 (0)	0 (0)	2	9 (45)	0 (0)	0 (0)
T3	0 (0)	12 (57.2)	0 (0)	III	8 (40)	1 (4.8)	0 (0)	3	3 (15)	4 (19)	0 (0)
T4	0 (0)	7 (33.3)	9 (100)	IV	1 (5)	15 (71.4)	2 (22.3)	4	0 (0)	5 (23.8)	0 (0)
P-value	<0.001			V	0 (0)	5 (23.8)	7 (77.7)	5	0 (0)	12 (57.2)	9 (100)
Total	20 (40)	21 (42)	9 (18)	P-value	<0.001			P-value	<0.001

Table 3 Comparison of different levels of mitosis in the specimens with and without lymphatic invasion

Lymphatic invasion	Mitotic level			Total	P-value
	0–1 Mitosis	2–3 Mitoses	≥4 Mitoses
Yes	1 (5%)	10 (47.6%)	5 (55.5%)	16 (32%)	0.003
No	19 (95%)	11 (52.4%)	4 (44.5%)	34 (68%)
Total	20 (100%)	21 (100%)	9 (100%)	50 (100%)