Risk and severity of psoriasis vulgaris in relation to angiotensin II type 1 receptor gene polymorphism and metabolic syndrome

Figures & data

Figure 1 Restriction enzyme analysis of the AT1R gene (A1166C) polymorphism. AA, CC, and AC genotypes are shown.

Table 1 Clinical and laboratory data among both studied groups

Variables	Mean ± SD		t-test	P-value
	Cases=25	Controls=25
Waist circumference WC	103.4±11.5 75–130	91.4±9.2 79 – 110	4.05	<0.001** H
Systolic blood pressure SBP	139.6±13.37 100–160	112.2±9.15 80–150	8.5	<0.001** H
Diastolic blood pressure DBP	90.4±9.24 65–100	79.6±8.36 60 – 110	5.71	<0.001** H
High density lipoprotein HDL	60.7±9.99 23–69	40.7±6.58 30–72	0.87	<0.001** H
Low density lipoprotein LDL	114.4±14.1 85 – 140	96.3±13.7 90 –137	4.69	<0.001** H
Total cholesterol TC	138.4±14.12 115 – 150	106.4±16.7 120 –160	7.3	<0.001** H
Triglycerides TRG	163.9±79.1 64 – 381	126.4±48.4 68–254	2.03	0.04 S
Fasting blood Glucose	108.4±27.3 78–203	111.95±43.22 81–275	0.351	0.727 NS

Note: **P-value<0.001 is highly significant, NS: P-value>0.05 is not significant, S: P-value>0.05.

Table 2 Assessment of metabolic syndrome among both studied groups

Variables	Mean ± SD		MW^#	P-value
	Cases=25	Controls=25
Metabolic score Range	0.72±0.59 0.03–3.83	0.42±0.31 0.02–4.17	2.57	0.01*
Metabolic percent Range	70.3±22.5 17.1 – 100	53.9±23.3 24.7–100	2.45	0.01*

Note: *P-value<0.05 is significant. ^#Mann-Whitney test of non-parametric data.

Table 3 Different genotype distribution of AT1R gene among both studied groups

Genotype	Group				X^2	P-value
	Cases (n=25)		Controls (n=25)
	N	%	N	%
AA (no polymorphism)	14	56	18	72	2.03	0.363 (NS)
AC (heterozygote)	10	40	7	28
CC (homozygote)	1	4	0	0.0

Table 4 Relation between the occurrence of metabolic syndrome among psoriasis patients and AT1R genotypes

	AT1R genotype groups			KW	P-value
	AA (n=14)	AC (n=10)	CC (n=1)
Metabolic percent
Mean ±SD	54.1±23.5	91.43±7.1	97.2	14.52	0.001
Range	17.1–89.5	76.4 – 100	—		(H)
Metabolic score
Mean ±SD	0.53±0.35	1.44±0.85	3.83	11.72	0.004
Range	0.03–1.18	0.48–3.1	—-		(S)

Note: Kruskal-Wallis test of non-parametric data, H: P-value≤0.001 is highly significant, S: P-value<0.05 is significant.