https://orcid.org/0000-0003-0974-9993
Figures & data
Figure 1 Holistic Beauty Wheel. Schematic map of the biological, environmental, and lifestyle factors influencing skin health and skin aging.
Figure 2 Representative images of Caucasian and Chinese skin. Representative images of 65 years old Caucasian and Chinese facial skin (Crow's Feet) captured with the Antera 3D camera. Starting from the left: normal mode showing images as perceived by the naked eye, wrinkle mode where depressions are highlighted with dark colours (the darker the deeper the wrinkle) and melanin mode where higher concentrations of melanin are rendered in darker orange color. Deeper wrinkles, yet less pigment spots, are observed in Caucasian skin compared to Chinese skin.
Figure 3 Example of anti-wrinkle benefits of multi-step regimen over 6 months. (A) Mean Crow’s feet wrinkle depth percentage reduction on the tested panel using a 4-step skin care regimen, as measured by the Antera 3D. Consistent and incremental efficacy could be observed over a period of 6 months. *Significance vs baseline (Repeated measures ANOVA with Dunnett post-hoc, P<0.05). (B) Representative image of one volunteer crow’s feet area at baseline and following 6 months of using the 4-step skin care regimen. The depression in the skin are depicted in lighter colours at 6 months, showing a reduced depth of the wrinkles.
Figure 4 Reported relationships and interactions from the literature between exposome/lifestyle factors, microbiome, and underlying physiological changes.
Figure 5 Skin interactome. Schematic view combining the various factors affecting skin health and skin aging in relation to the “genome-microbiome-exposome” (GME) interfaces.
Figure 6 Skin interactome approach applied to the generation of a Collagen1A1/Collagen4A1 molecular network model (A) and example of application of Network Pharmacognosy for the determination of the suitable natural plant extract in boosting pro-collagen production (B).
Figure 7 Genome-microbiome-exposome key´s interaction and the effects in the collagens skin homeostasis through the mediation of ROS. The illustration shows nodes (proteins) and their interactions obtained by literature data evaluation of an upstream Pi-Pi network for COL1A1, COL1A2, COL3A1, COL4A2 in human cells and the interaction with UV, ROS, Pollution (Diesel Particulate Matter), and Skin Microbiome.
