Correlation Between Glutathione Plasma with Degree Severity of Melasma in Balinese Women

Figures & data

Table 1 Characteristics of the Study

Characteristics	n=47	Plasma GSH (µmol/L)	p
Sex
Male	5 (10.6%)	1.73 ± 0.12	0.422
Female	42 (89.4%)	1.82 ± 0.34
Age
31–40 years	13 (27.7%)	2.03 ± 0.20	0.022*
41–50 years	25 (53.2%)	1.74 ± 0.31
51–60 years	9 (19.1%)	1.71 ± 0.37
Skin type (Fitzpatrick)
IV	26 (55.3%)	1.82 ± 0.35	0.751
V	21 (44.7%)	1.81 ± 0.29
Family history of melasma
Yes	35 (74.5%)	1.79 ± 0.32	0.369
No	12 (25.5%)	1.86 ± 0.33
Daily UV exposure
30 minute–3 hours	13 (27.6%)	1.94 ± 0.33	0.052
3–6 hours	21 (44.7%)	1.81 ± 0.35
6–9 hours	7 (14.9%)	1.72 ± 0.32
9–12 hours	6 (12.8%)	1.68 ± 0.02
Melasma pattern
Malar	8 (17%)	2.03 ± 0.27	0.073
Dentofacial	37 (87.7%)	1.77 ± 0.32
Mandibular	2 (4.3%)	1.81 ± 0.20
Type of melasma
Epidermal	7 (14.9%)	1.88 ± 0.21	0.216
Dermal	4 (8.5%)	1.93 ± 0.47
Mixed	36 (76.6%)	1.79 ± 0.32
Severity of melasma (MASI)
Mild	38 (80.85%)	1.89 ± 0.28	0.043*
Moderate	7 (14.89%)	1.53 ± 0.13
Severe	2 (4.25%)	1.18 ± 0.20

Note: *Significant (p<0.05).

Abbreviations: GSH, glutathione; MASI, melasma area severity index; UV, ultraviolet.

Table 2 Partial Correlation Model Between Plasma Glutathione and MASI Score

Variable	MASI Score
Glutathione plasma	r	−0.624
	p	<0.001*
	n	47

Note: *Significant (p<0.05).

Abbreviation: MASI, melasma area severity index.

Figure 1 Scatter plot correlation between melasma area severity index score with glutathione plasma shows a downward line (negative correlation).

Table 3 Linear Regression Analysis on Plasma Glutathione with the Severity of Melasma Based on MASI Score

Variable	β	R^2	p
GSH	−0.62	58.2	<0.001*

Note: *Significant (p<0.05).

Abbreviations: GSH, glutathione; MASI, melasma area severity index.