Both Age and Disease Duration are Associated with Clinical Phenotype of Hori’s Nevus in Chinese: A Retrospective Analysis of 497 Cases

Figures & data

Table 1 Demographic Characteristics of Subjects

	Females (N=486)	Males (n=11)	Overall (N=497)
Age (years) (Mean ± SEM, 95% CI)	26.88 ± 0.26; 95% CI 26.36–27.40	25.09 ± 1.05; 95% CI 22.75–27.43	26.84 ± 0.26; 95% CI 26.33–27.35
Age (years) at nset (Mean ± SEM, 95% CI)	18.99 ± 0.24; 95% CI 18.51–19.47	20.64 ± 1.01; 95% CI 18.38–22.89	19.02 ± 0.24; 95% CI 18.55–19.49
Disease duration (years) (Mean ± SEM, 95% CI)	7.90 ± 0.21*; 95% CI 7.491–8.303	4.46 ± 0.76; 95% CI 2.772–6.137	7.82 ± 0.20; 95% CI 7.42–8.222
Fitzpatrick Skin Type (n, %)
Type III	65 (13)	0	65 (13)
Type IV	421 (87)	11 (100)	432 (87)

Notes: *p=0.0129 vs males; t=2.495.

Figure 1 Clinical and dermoscopic images. Black arrows indicate involvement of pigment in hair follicles.

Figure 2 Age-associated characteristics of involved areas. The number of patients with extra zygomatic involvement increases with age. Chi-square test for trend was used to analyze the trend of changes. Significances are indicated in the figures.

Figure 3 Age- and disease duration-associated lesion color. (A) displays lesion color among different age groups. The tendency of having slate-grey color of lesions increases with age (Chi-square=3.844, p=0.0499 for slate-grey color); (B) exhibits variation of lesion color with age at onset. The tendency of having yellow-brown color of lesions increases with age at onset (Chi-square=30.92, p<0.0001 for yellow-brown color); (C) demonstrates variation of lesion color with disease duration (Chi-square=239.5, p<0.0001 for yellow-brown color; Chi-square=95.51, p<0.0001 for slate grey color). Chi-square test for trend was used to determine the significance.

Table 2 Disease Duration-Related Clinical Characteristics

Duration (years)	Gender (N)	Involved Sites [N (%)]
		Zygomatic Area	Lower Eyelid	Root of the Nose	Alae of the Nose	Temple	Forehead
1–5	Females (178)	178 (100)	12 (7)^d	7 (4)^d	1 (1)^d	9 (5)^d	20 (11)^d
	Males (8)	8 (100)	0^c	0^c	1 (13)^b	0^c	3 (38)^a
6–10	Females (240)	239 (100)	13 (5)^d	14 (6)^d	8 (3)^d	20 (8)^d	22 (9)^d
	Males (3)	3 (100)	0	0	0	0	1 (33)
11–15	Females (38)	38 (100)	5 (13)^d	2 (5)^d	0^d	7 (18)^d	4 (11)^d
	Males (0)	0	0	0	0	0	0
16–20	Females (23)	23 (100)	3 (13)^d	2 (9)^d	2 (9)^d	7 (30)^d	5 (22)^d
	Males (0)	0	0	0	0	0	0
>20	Females (7)	7 (100)	2 (29)^a	2 (29)^a	0^c	1 (14)^b	2 (29)^a
	Males (0)	0	0	0	0	0	0

Notes: Fisher’s exact test was used to analyze significance in prevalence. ^ap<0.05, ^bp<0.01, ^cp<0.001, and ^dp<0.0001 between the zygomatic area and other areas. No significant differences were found between males and females.