Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders

Figures & data

Figure 1 Schematic representation of the key components of the ECS in different cellular compartments of the skin.

Figure 2 Modulation of the ECS by endocannabinoids and phytocannabinoids in presynaptic neurons in the central and peripheral nervous systems.

Figure 3 Chemical Structures of 9 endocannabinoids found in human skin.

Figure 4 Chemical structures of the most common phytocannabinoids found in the hemp plant.

Table 1 Examples of Phytochemicals Targeting the ECS with Phytocannabinoid-Like Activity

Ingredient	Chemical Classification	Plant Source(s)	Mechanism of Actions	Potential Therapeutic Actions
Limonene	Terpene	Citrus fruits	Glutathione upregulation^Citation143	Antioxidant, antitumor activity^Citation143
β-Carophyllene (BCP)	Sesquiterpene	Hops, Copaiba, black pepper, rosemary, hemp essential oil^Citation144	CB2 receptor agonism^Citation145,Citation146	Anxiolytic, antinociceptive^Citation144,^Citation146^–^Citation148
Echinacea	Alkylamides	Echinacea, Sichuan pepper	CB2 receptor agonism^Citation149^–^Citation151	Anti-inflammatory^Citation152, antimicrobial^Citation153, antioxidant^Citation154
Turmeric	Curcuminoids	Turmeric	CB1 receptor agonism^Citation155	Anti-inflammatory and antinociceptive properties^Citation156
Boswellic acids	Triterpenes	Frankincense	Inhibition of PGE2 (Prostaglandin E2) synthase^Citation157	Anti-inflammatory^Citation157
Magnolia	Polyphenols	Magnolia bark	CB2 receptor agonism^Citation158	Antioxidant, anti-inflammatory^Citation159
Ashwagandha	Lactones and steroidal alkaloids	Withania somnifera	Potential GABA mimetic action^Citation160	Immuno-modulatory, stress reduction^Citation160

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