Both Prevalence and Severity of Pruritus are Associated with Age in Chinese Patients with Skin Diseases

Figures & data

Table 1 Age Distribution of Skin Disorders

Skin Disorders (N, %)	Age (years) [Mean±SEM (N, Range, 95% CI)]		*Significance (Males vs Females)
	Males (N=864)	Females (N=1246)
Acne (371, 17.58%)	^b20.94±0.57 (170, 13–86, 19.82–22.06)	^b,e23.03±0.52 (201, 13–84, 22.02–24.05)	p<0.0001
Acute herpes zoster (27, 1.58%)	54.92±6.04 (13, 22–79, 41.75–68.09)	53.00±4.76 (14, 23–74, 42.72–63.28)	NS
Eczematous dermatitis (367, 17.39%)	49.65±1.73 (143, 13–94, 46.24–53.06)	^a38.63±1.15 (224, 13–92, 36.36–40.89)	p<0.0001
Folliculitis (75, 3.55%)	^b22.91±1.75 (33, 14–67, 19.35–26.47)	^b,e25.26±1.18 (42, 14–50, 22.88–27.64)	NS
Malassezia folliculitis (45, 2.13%)	^b22.35±1.71 (26, 13–54, 18.82–25.87)	^b,e23.42±1.45 (19, 13–34, 20.37–26.47)	NS
Psoriasis (36, 1.71%)	^b33.21±3.93 (19, 14–67, 24.96–41.46)	^a33.00±4.80 (17, 13–78, 22.83–43.17)	NS
Seborrheic dermatitis (66, 3.13%)	^a38.12±3.77 (17, 18–61, 30.12–46.11)	^b,d31.20±1.60 (49, 16–66, 27.99–34.42)	NS
Tinea (143, 6.78%)	^b33.96±2.03 (71, 13–85, 29.91–38.00)	^a38.35±1.71 (72, 14–88, 34.93–41.76)	p<0.05
Urticaria (295, 13.98%)	^b33.78±1.70 (97, 13–74, 30.42–37.15)	^b35.30±1.03 (198, 14–78, 33.27–37.33)	NS
Verruca vulgaris (39, 1.85%)	^b27.35±3.31 (17, 13–63, 20.34–34.36)	^a34.64±3.82 (22, 14–72, 26.69–42.59)	p<0.05
Others (646, 30.62%)	^b36.10±1.13 (258, 13–90, 33.87–38.33)	^a,c35.28±0.81 (388, 13–87, 33.32–36.44)	NS
^#Significance among Disorders	^ap<0.05, ^bp<0.001 vs herpes zoster and eczema; p<0.05 acne vs all except folliculitis, malassezia folliculitis, and verruca vulgaris	^ap<0.01, ^bp<0.001 vs herpes zoster; ^cp<0.05, ^dp<0.01, ^ep<0.001, vs eczematous dermatitis. p<0.05 acne vs all except folliculitis and malassezia folliculitis

Notes: Methods of statistical analyses: *unpaired student’s t test; ^#one way ANOVA analysis.

Table 2 Comparison of Pruritus Between Males and Females

Diseases (N)	Prevalence of Pruritus [%, (n)]		Severity of Pruritus (VAS) (Mean±SEM)			Significance (Males vs Females)
	Males	Females	Males	Females
Acne (371)	45% (77)	46% (93)	1.28±0.14	1.34±0.12		NS
Acute herpes zoster (27)	62% (8)	36% (5)	1.92±0.66	1.21±0.48		NS
Eczematous dermatitis (367)	83% (119)	81% (182)	^c3.95±0.20	^e3.90±0.16		NS
Folliculitis (75)	21% (7)	29% (12)	0.45±0.16	0.64±0.17		NS
Malassezia folliculitis (45)	57% (15)	79% (15)	1.58±0.32	2.26±0.35		NS
Psoriasis (36)	58% (11)	53% (9)	^b2.74±0.63	2.18±0.64		NS
Seborrheic dermatitis (66)	65% (11)	71% (35)	^a2.47±0.59	^e2.88±0.32		NS
Tinea (143)	72% (51)	65% (47)	^c3.00±0.29	^e2.75±0.28		NS
Urticaria (295)	92% (89)	93% (184)	^c,d5.31±0.24	^d,e5.39±0.18		NS
Verruca vulgaris (39)	^@41% (7)	14% (3)	*1.29±0.41	0.55±0.38		*p<0.05; ^@p=0.0508
Others (646)	^@59% (152)	48% (187)	*^c2.74±0.17	1.81±0.12		*p<0.0001; ^@p=0.008
Overall (2110)	63% (547)	62% (772)	2.79±0.09	2.72±0.08		NS
	X^Citation2=115.7, ^@p<0.0001	X^Citation2=226.8, ^@p<0.0001	^dp<0.0001 vs all; ^ap<0.05, ^bp<0.01,^cp<0.001 vs Folliculitis	^dp<0.0001 vs all; ^ep<0.001 vs Verruca vulgaris

Notes: Methods of statistical analyses: *unpaired Student’s t-test; ^a-eone way ANOVA analysis; ^@Chi-square test.

Figure 1 Prevalence and intensity of pruritus. (A) The prevalence of pruritus in common skin disorders. Chi-square test was used to analyze significance of differences in prevalence among skin disorders (X²=370.0, p<0.0001). (B) VAS of pruritus. Data are expressed as mean±SEM. One-way ANOVA analysis was used to determine the significance of variation in VAS among skin disorders, p<0.0001.

Abbreviation: GC, Glucocorticoids.

Figure 2 Association of skin type with prevalence and intensity of pruritus. (A) Prevalence of pruritus in different types of skin. (B) Association of VAS of pruritus with skin type. way ANOVA analysis was used to determine the significance of variation in VAS among skin types. Data are expressed as mean±SEM. Significances between males and females were determined using unpaired Student’s t-test.

Swarna SS, Aziz K, Zubair T, et al. Pruritus associated with chronic kidney disease: a comprehensive literature review. Cureus. 2019;11(7):e5256.

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