Long-term efficacy, safety and durability of Juvéderm® XC

Figures & data

Table 1 Characteristics of most commonly used FDA-approved hyaluronic acid dermal fillers

	Restylane®*	Perlane®*	Juvéderm® Ultra*	Juvéderm® Ultra Plus*	Belotero®
Manufacturer	Medicis	Medicis	Aller`gan	Allergan	Merz
FDA approval	2003	2007	2006	2006	2012
HA concentration	20 mg/mL	20 mg/mL	24 mg/mL	24 mg/mL	22.5 mg/mL
Form	Particle 125 μm 100,000/mL	Particle 325 μm 10,000/mL	Homogeneous	Homogeneous	Homogeneous
Cross-linker	BDE	BDE	BDE (9%)	BDE (11%)	BDE
Type of gel	Biphasic	Biphasic	Monophasic monodensified	Monophasic monodensified	Monophasic polydensified
Gel hardness	513 Pa**	541 Pa**	28 Pa**	75 Pa**	–

Notes:

* The manufacturers of Restylane-L®, Perlane-L®, Juvéderm® Plus XC, and Juvéderm® Ultra Plus XC claim that these products have the same characteristics as their respective lidocaine free versions

** Sundaram H, et al.⁵ – this information is not available.

Abbreviations: BDE, 1,4-butanediol-diglycidyl-ether; FDA, Food and Drug Administration.

Table 2 FDA-approved hyaluronic acid dermal fillers manu factured with 0.3% lidocaine

With 0.3% lidocaine	Company
Restylane-L®	Medicis
Perlane-L®	Medicis
Juvéderm® Ultra XC	Allergan
Juvéderm® Ultra Plus XC	Allergan
Prevelle® Silk	Mentor
Hydrelle™	Coapt Systems Inc

Note: Company locations are as follows: Medicis Aesthetics, Scottsdale, AZ, USA; Allergan, Inc, Irvine, CA, USA; Mentor, Santa Barbara, CA, USA; Coapt Systems, Palo Alto, CA, USA.

Abbreviation: FDA, Food and Drug Administration.

Table 3 Articles comparing Juvéderm® XC versus hyaluronic acid dermal fillers manufactured without lidocaine

Authors	Journal	n	HA dermal fillers compared	Safety	Efficacy	Longevity
Levy et al^Citation18,Citation20	Journal of Cosmetic and Laser Therapy	126	Restylane-Perlane® X Juvéderm® Ultra XC	Similar	Similar	Not studied
Levy et al^Citation18,Citation20	Dermatologic Surgery	60	Juvéderm® Ultra X Juvéderm® Ultra XC	Similar	Similar	Not studied
Weinkle et al^Citation22	Journal of Cosmetic Dermatology	72	Juvéderm® Ultra X Juvéderm® Ultra XC	Similar	Similar	Not studied
Prager et al^Citation9	Dermatologic Surgery	20	Belotero® X Juvéderm® Ultra XC	Similar	Similar	Similar*

Note:

* except for 4-week evenness results.

SundaramHVoigtsBBeerKMelandMComparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acidDermatol Surg2010361859186520969663

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LevyPMBoulleKRaspaldoHComparison of injection comfort of a new category of cohesive hyaluronic acid filler with preincorporated lidocaine and a hyaluronic acid filler aloneDermatol Surg20093533233719207322

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LevyPMDe BoulleKRaspaldoHA split-face comparison of a new hyaluronic acid facial filler containing pre-incorporated lidocaine versus a standard hyaluronic acid facial filler in the treatment of nasolabial foldsJ Cosmet and Laser Ther200911316917319337944

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WeinkleSHBankDEBoydCMGoldMHThomasJAMurphyDKA multi-center, double-blind, randomized controlled study of the safety and effectiveness of Juvéderm injectable gel with and without lidocaineJ Cosmet Dermatol20098320521019735519

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PragerWWissmuellerEHavermannIA prospective, split-face, randomized, comparative study of safety and 12-month longevity of three formulations of hyaluronic acid dermal filler for treatment of nasolabial foldsDermatol Surg2012387 Pt 21143115022759250

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