Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebocontrolled, double-blind study

Figures & data

Table 1 Inclusion criteria

Healthy female (70%) and male (30%) subjects

Age 35–65 years (50% aged 35–50 years and 50% aged 51–65 years)

Caucasian race

Dull complexion

Body mass index in the optimal (20–25) range for both male and female subjects

Cutaneous dyschromia/brown spots (present in at least 60% of participants)

Subjects who have not participated in similar studies in the 2 months prior to the current study

Absence of skin diseases

Undertaking not to change their normal daily routine

Commitment not to use products having activity comparable with that of the product to be tested during the study period

Commitment not to use face creams during the study period

Promise not to change eating habits during the study period

Agreeable to signing an informed consent form

Figure 1 Antioxidant evaluation. (A) Derivatives of reactive oxygen metabolites test (Carratelli units). (B) Oxyadsorbent test (mmol HClO/L) both as a function of time in days (dd).

Notes: Data are reported as the mean ± standard error of the mean. Intergroup statistical analysis (active versus placebo) is reported inside the bars of the histogram. The lines report the intragroup statistical analysis (T60 vs T0). Statistical analysis is marked with (*) in increasing numbers depending on significance.
Abbreviation: d-ROMs, derivatives of reactive oxygen metabolites test.

Figure 2 Skin Antioxidant capacity: FRAP test- (μmol Fe²⁺/L) as a function of time in days (dd).

Notes: Data are reported as mean ± SEM. Intergroup statistical analysis (active vs placebo) is reported inside the bars of the histogram. The lines report the intragroup statistical analysis (T60 vs T0). Statistical analysis is marked with (*) in increasing numbers depending on significance.
Abbreviation: FRAP test, ferric-reducing ability of plasma test.

Figure 3 Skin antiaging effect. (A) Skin moisturization (corneometric units). (B) Skin elasticity (R2 parameter) – (Ua/Uf ratio) both as a function of time in days (dd).

Notes: Data are reported as the mean ± standard error of the mean. Intergroup statistical analysis (active versus placebo) is reported inside the bars of the histogram. The lines report the intragroup statistical analysis (T60 vs T0). Statistical analysis is marked with (*) in increasing numbers depending on significance.

Figure 4 Skin surface (μm). (A) Skin roughness. (B) Wrinkle depth, both as a function of time in days (dd).

Notes: Data are reported as the mean ± standard error of the mean. Intergroup statistical analysis (active versus placebo) is reported inside the bars of the histogram. The lines report the intragroup statistical analysis (T60 vs T0). Statistical analysis is marked with (*) in increasing numbers depending on significance.

Figure 5 Intensity of brown spot: ITA° - grades (°) as a function of time in days (dd).

Notes: Data are reported as the mean ± standard error of the mean. Intergroup statistical analysis (active versus placebo) is reported inside the bars of the histogram. The lines report the intragroup statistical analysis (T60 vs T0). Statistical analysis is marked with (*) in increasing numbers depending on significance.