https://orcid.org/0000-0003-3900-5506
Figures & data
Table 1 Composition of NCTF 135HA (Approved CE Marking Medical Device)
Table 2 Amount of Product Injected According to the Skin Aging Grade (Bazin Cheek Folds Score)
Figure 1 Face injection procedure according to the fan technique. Vector A: Entry point by zygomatic arch; Vector B: Entry point above the mandibular angle; Vector C: Entry point beside the oral commissure. The black arrows indicates the injection lines of the filler and the red arrows indicates the injection lines of the NCTF®134HA.
Table 3 Clinical Assessments Used by the Investigators to Obtain Objective Evaluations of the Treatment Evolution
Figure 2 Bazin cheek wrinkles scale.
Figure 3 Mean wrinkles score assessed on cheek folds by Bazin scale and mean skin radiance score from very dull skin (Grade 4) to very radiant skin (Grade 0) AT D0, D30, and D120 after BIONUTRILIFT injection treatment. Statistical significances of the changes experienced at each time point compared to the baseline (D0) are shown as *p≤0.0001.
Figure 4 Evolution of global mean wrinkles score assessed on marionette lines, NSL folds and upper lips at D0, D30 and D120 by Bazin scale combined treatment (three vectors). Statistical significances of the changes experienced at each time point compared to the baseline (D0) are shown as *p≤0.0001.
Figure 5 Evolution of mean wrinkles score assessed on marionette lines, NSL folds and upper lips at D0, D30 and D120 by Bazin scale combined treatment (vectors A+B (A) and only vector C (B)). Statistical significances of the changes experienced at each time point compared to the baseline (D0) are shown as *p≤0.0001; **p<0.0006.
Figure 6 Investigator and subject satisfaction rate (%) of the new protocol BIONUTRILIFT evaluated by GAIS.
Figure 7 Before-after photos. Exemplary photographs illustrating before the treatment. (A) A female subject with a baseline score of 5 on the Bazin cheek folds wrinkle scale (left photo, D0) and after the treatment with three vectors with a score of 2 at D30 (middle photo), and a score of 1 at D120 (right photo). (B) The before-after photos on nasolabial fold of a female subject with the score of 5 on the Bazin nasolabial fold score at baseline (left photo) which decreased to score 3 at D30 (middle photo). This score remained stable at 3 at D120 (right photo) (C) The before-after photos of a female subject on cheek folds with a score of 7 on the Bazin cheek fold scale at baseline (left photo) which decreased to 5 at D30 (middle photo) and to 4 at D120 (right photo).
Figure 8 Local adverse events.
