Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus

Figures & data

Figure 1 HE staining of LP (case group) showing hyperkeratosis of the epidermis, band like infiltration of lymphocytes.(HE x 100).

Table 1 Comparison of Demographic Details of Two Groups

Group	n	Sex (M/F)	Age (Years)
Case	30	17 /13	40.43±9.96
Control	10	5/5	43.80±11.93
P		P>0.05	P>0.05

Table 2 Positive Expression Rates of TNF-α and NF-κB/p65 (%)

Group	n	TNF-α					X^2	NF-κB/p65					X^2
		-	+	++	+++	Positive %		-	+	++	+++	Positive%
Case	30	6	9	10	5	24 (80.0)*	4.02	8	8	10	4	22 (73.3)^#	3.17
Control	10	9	1	0	0	1 (10)*		9	1	0	0	1 (10)^#

Note: *P ≤ 0.05, ^#P ≤ 0.05 compared with control group.

Table 3 Comparison of TNF-α and NF-κB/p65 Expression Levels in Tissue of LP Group and Control Group ( ± s)

Group	n	TNF-α	NF-κB/p65
Case	30	30.37±17.99*	28.47±18.08^▲
Control	10	9.40±2.55*	9.90±3.90^▲
t/χ2		3.64	3.20
P		P<0.01	P<0.01

Note: *P ≤ 0.05, ^▲P ≤ 0.05 compared with control group.

Figure 2 Immunohistochemical staining of TNF-α in case group (Brownish-yellow particles in the cytoplasm) (A) TNF-α weak staining (magnification, x200), (B) TNF-α moderate staining (magnification, x200), (C) TNF-α strong staining (magnification, x200), (D) TNF-α negative staining in control group (magnification, x200).

Figure 3 Immunohistochemical staining of NF-κB/p65 in case group (Brownish-yellow particles in the nucleus and cytoplasm) (A) NF-κB/p65 weak staining (magnification, x200), (B) NF-κB/p65 moderate staining (magnification, x200), (C) NF-κB/p65 strong staining (magnification, x200), (D) NF-κB/p65 negative staining in control group (magnification, x200).