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CASE REPORT

Localized Plaques on the Scalp as Initial Presentation of Multicentric Plasmacytic Castleman Disease

ORCID Icon, , & ORCID Icon
Pages 1833-1836 | Received 25 Jul 2022, Accepted 05 Sep 2022, Published online: 08 Sep 2022

Figures & data

Figure 1 (A and B) Multiple irregular-shaped, dark-red, soft to fluctuant, well-demarcated, and infiltrated plaques ranging in size from 1 to 8 cm in diameter disseminating on the head.

Figure 1 (A and B) Multiple irregular-shaped, dark-red, soft to fluctuant, well-demarcated, and infiltrated plaques ranging in size from 1 to 8 cm in diameter disseminating on the head.

Figure 2 (A) Histopathology showed that small lymphocytes of the mantle zones are arranged in concentric rings around the atrophied germinal center, and amounts of plasma cells in the interfollicular region (HE, A×100). The immunohistochemistry results of CD3 (a, ×40), CD20 (b, ×40), Ki67 (c, ×40), CD38 (d, ×40), CD138 (e, ×40), Kappa (f, ×40), Lambda (g, ×40), BCL-2 (h, ×40), CD21 (i, ×40), CD34 (j, ×40), IgG (k, ×40), IgG4 (l, ×40).

Figure 2 (A) Histopathology showed that small lymphocytes of the mantle zones are arranged in concentric rings around the atrophied germinal center, and amounts of plasma cells in the interfollicular region (HE, A×100). The immunohistochemistry results of CD3 (a, ×40), CD20 (b, ×40), Ki67 (c, ×40), CD38 (d, ×40), CD138 (e, ×40), Kappa (f, ×40), Lambda (g, ×40), BCL-2 (h, ×40), CD21 (i, ×40), CD34 (j, ×40), IgG (k, ×40), IgG4 (l, ×40).

Figure 3 (A and B), (A) showed reactive lymphoid follicular hyperplasia within the dermis. (B) revealed neutrophil and plenty of plasma cells infiltration. (HE, A×40, B×200). The immunohistochemistry results of CD3 (a, ×40), CD20 (b, ×40), CD38 (c, ×40), CD138 (d, ×40), IgG (e, ×40), IgG4 (f, ×40), CD34 (g, ×40), Kappa (h, ×40), Lambda (i, ×40), BCL-2 (j, ×40) and Ki-67 (k, ×40).

Figure 3 (A and B), (A) showed reactive lymphoid follicular hyperplasia within the dermis. (B) revealed neutrophil and plenty of plasma cells infiltration. (HE, A×40, B×200). The immunohistochemistry results of CD3 (a, ×40), CD20 (b, ×40), CD38 (c, ×40), CD138 (d, ×40), IgG (e, ×40), IgG4 (f, ×40), CD34 (g, ×40), Kappa (h, ×40), Lambda (i, ×40), BCL-2 (j, ×40) and Ki-67 (k, ×40).