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CASE REPORT

SAPHO Syndrome with Palmoplantar Pustulosis as the First Manifestation Successfully Treated with Adalimumab

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Pages 2547-2554 | Received 30 Jul 2022, Accepted 17 Nov 2022, Published online: 28 Nov 2022

Figures & data

Figure 1 Scattered patchy erythema and pustules on the palms of both hands and the soles (A). The palmoplantar pustules were alleviated after treatment (B).

Figure 1 Scattered patchy erythema and pustules on the palms of both hands and the soles (A). The palmoplantar pustules were alleviated after treatment (B).

Figure 2 Skin biopsy pathology of the left hand revealed that the patient suffered from skin hyperkeratosis, with a few focal purulent exudates, epidermal hyperplasia, hypertrophy of the spinous layer and hyperplasia of the epithelium of the epidermis with lymphocytic infiltration.

Figure 2 Skin biopsy pathology of the left hand revealed that the patient suffered from skin hyperkeratosis, with a few focal purulent exudates, epidermal hyperplasia, hypertrophy of the spinous layer and hyperplasia of the epithelium of the epidermis with lymphocytic infiltration.

Figure 3 MRI of the thoracic spine shows abnormal signal lesions in the 5th, 8th, 9th, and 10th thoracic spine (T5, T8, T9, and T10).

Figure 3 MRI of the thoracic spine shows abnormal signal lesions in the 5th, 8th, 9th, and 10th thoracic spine (T5, T8, T9, and T10).

Figure 4 PET-CT presented abnormal glucose metabolism with bone alteration in the 1st right sternocostal joint, sternal body, the T5, T8, T9, and T10, and the 4th lumbar vertebra (L4), with a high possibility of a malignant lesion.

Figure 4 PET-CT presented abnormal glucose metabolism with bone alteration in the 1st right sternocostal joint, sternal body, the T5, T8, T9, and T10, and the 4th lumbar vertebra (L4), with a high possibility of a malignant lesion.

Figure 5 ECT showed that radiologically distributed thickening appeared in the 1st anterior right rib, right sternoclavicular joint, and right upper tibia ().

Figure 5 ECT showed that radiologically distributed thickening appeared in the 1st anterior right rib, right sternoclavicular joint, and right upper tibia (Figure 1F).

Figure 6 The patient’s vertebral biopsy pathology report did not suggest tumor cells, but only a few broken bones, sequestrums, and bone marrow.

Figure 6 The patient’s vertebral biopsy pathology report did not suggest tumor cells, but only a few broken bones, sequestrums, and bone marrow.

Figure 7 Pustular lesion on the anterior chest and back.

Figure 7 Pustular lesion on the anterior chest and back.