Thermal waters as cosmeceuticals: La Roche-Posay thermal spring water example

Figures & data

Table 1 Physicochemical analysis of La Roche-Posay thermal spring water

pH	7	Silicate	31.6 mg/L
Temperature	13°C	Magnesium	4.4 mg/L
Resistance	1540 Ω	Strontium	0.3 mg/L
Dry residues	595 mg/L	Selenium	0.053 mg/L
Bicarbonate	387 mg/L	Zinc	<0.005 mg/L
Calcium	149 mg/L	Copper	<0.005 mg/L

Table 2 Effect of selenium and La Roche-Posay thermal spring water on lipid peroxidation and selenium-glutathione peroxidase activity in human skin fibroblasts exposed to ultraviolet A

	TBARS (nmol/mg)	Se-GSH · Px (mU/mg)
Donor 1
Medium 1	3.06 ± 0.23	10.5 ± 2.1
Medium 2	1.40 ± 0.15*	46.8 ± 1.6*
Medium 3	1.10 ± 0.01*	48.2 ± 1.9*
Donor 2
Medium 1	1.30 ± 0.02	29.8 ± 1.4
Medium 2	0.89 ± 0.09*	39.8 ± 0.9*
Medium 3	1.09 ± 0.02*	41.7 ± 2.9*
Donor 3
Medium 1	3.06 ± 0.05	12.3 ± 1.6
Medium 2	1.70 ± 0.09*	45.0 ± 2.1*
Medium 3	2.09 ± 0.14*	45.8 ± 1.6*

Notes: Data are normalized to cell protein content and are shown as the mean ± standard deviation of triplicate measurements for each donor. TBARS were measured in the supernatant after ultraviolet A exposure. Data for a given donor were determined from the same cell culture.

* P < 0.05 versus medium 1.

Abbreviations: TBARS, thiobarbituric acid reactive substances; Se-GSH · Px, selenium-glutathione peroxidase.

Figure 1 (A–C) Modulation of cytokine concentrations in supernatants of control and inflammatory reconstituted skin cultured in media containing different salts, demineralized water, or La Roche-Posay thermal spring water.¹⁰

Note: Results are expressed as the percentage increase according to expression on days 10–14 × 100/day 10.
Abbreviations: C, control medium with demineralized water; IL, interleukin; SrNO₃, strontium nitrate; SrCl₂, strontium chloride; SeCl₂, selenium chloride; SeNaO₃, sodium selenate; SeNaO₄, sodium selenite; TNF, tumor necrosis factor.

Figure 2 Protective effect of La Roche-Posay thermal spring water on the incidence of skin tumors (A) and on number of tumors per survivors (B) following repeated ultraviolet B exposure.¹¹

CélérierPRichardARougierALitouxPDrenoBModulatory effects of selenium and strontium salts on keratinocyte-derived inflammatory cytokinesEur J Dermatol200212LVILVIII12120607

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CadiRBeaniJCBelangerSProtective effect of a selenium-rich thermal water on UVB induced skin carcinogenesisNouv Dermatol199110266272 French

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