Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review

Figures & data

Figure 1 Flow diagram of literature selection and screening in this study.

Figure 2 Overall distribution of publication outputs of PDT on skin cancer. (A) Global annual output trends of PDT on skin cancer. (B) The growth trends of publications related to PDT on skin cancer of the top five countries.

Table 1 Top 10 Countries in the Field of PDT on Skin Cancer

Rank	Country	Publications	Percentage	H-Index	ACI
1	USA	627	23.55%	80	39.14
2	China	289	10.86%	41	24.28
3	Germany	263	9.88%	58	43.43
4	England	236	8.87%	58.31	59
5	Italy	157	5.90%	38	29.4
6	Brazil	149	5.60%	33	24.74
7	Netherlands	140	5.26%	47	54.38
8	Japan	106	3.98%	28	26.63
9	France	93	3.49%	35	50.75
10	Scotland	90	3.38%	38	66.2

Abbreviation: ACI, average citation index.

Figure 3 The contributions and cooperation of countries/regions in the field of PDT on skin cancer. Circles with larger diameters represent countries with more publications.

Table 2 Top 10 Institutions in the Field of PDT on Skin Cancer

Rank	Organization	Publications	Percentage	H-Index	ACI
1	Harvard University	92	3.46%	43	60.15
2	Universidade de Sao Paulo	83	3.12%	26	25.66
3	University of London	83	3.12%	32	50.39
4	University of Copenhagen	77	2.89%	34	40.56
5	Massachusetts General Hospital	70	2.63%	37	54.91
6	University of California System	69	2.59%	27	36.12
7	University of Oslo	64	2.40%	31	63.63
8	Erasmus University Rotterdam	62	2.33%	26	41.06
9	Bispebjerg Hospital	59	2.22%	28	44.66
10	Erasmus MC	59	2.22%	25	39.76

Abbreviation: ACI, average citation index.

Figure 4 The contributions and cooperation of different institutions focusing on PDT on skin cancer. Circles with larger diameters represent institutions with more publications.

Table 3 Top 10 Authors in the Field of PDT on Skin Cancer

Rank	Author	Country	Institutes	Publications	H-Index	ACI
1	Szeimies RM	Germany	Klinikum Vest GmbH	59	34	67
2	Moan J	Norway	Rigshosp, Radiumhosp Med Ctr, Inst Canc Res	44	25	65.7
3	Haedersdal M	Denmark	Bispebjerg Hosp	38	23	40.58
4	Morton CA	Scotland	Stirling Community Hosp	35	26	110.57
5	Robinson DJ	Netherlands	Erasmus MC, Univ Hosp	30	18	44.6
6	Wulf HC	Denmark	Copenhagen Univ Hosp	30	20	45.9
7	Wang XL	China	Tongji Univ	28	13	16.68
8	Juzeniene A	Norway	Oslo Univ Hosp	25	14	38.96
9	De Bruijn HS	Netherlands	Erasmus Univ	24	15	41.92
10	Tedesco AC	Brazil	Univ Sao Paulo	24	18	37.46

Abbreviation: ACI, average citation index.

Figure 5 Visual cluster analysis of top authors in the field of PDT on skin cancer. Circles with larger diameters represent authors with more publications.

Table 4 Top 10 Journals in the Field of PDT on Skin Cancer

Rank	Journal	Publications	Percentage	H-Index	ACI	JCR
1	Photodiagnosis and Photodynamic Therapy	187	7.02%	27	16.9	Q3
2	British Journal of Dermatology	134	5.03%	55	69.37	Q1
3	Journal of Photochemistry and Photobiology B Biology	86	3.23%	33	54.92	Q1
4	Photochemistry and Photobiology	84	3.16%	32	48.42	Q2
5	Lasers in Surgery and Medicine	79	2.97%	28	30.3	Q1
6	Journal of the European Academy of Dermatology and Venereology	62	2.33%	30	41.98	Q1
7	Photodermatology Photoimmunology Photomedicine	49	1.84%	20	28.33	Q2
8	Dermatologic Surgery	46	1.73%	26	35.52	Q2
9	Lasers in Medical Science	46	1.73%	18	26.26	Q2
10	Journal of the American Academy of Dermatology	44	1.65%	25	71.07	Q1

Abbreviation: ACI, average citation index.

Table 5 Top 10 Most Cited Publications in the Field of PDT on Skin Cancer

Rank	Publications	First Author	Journal	Year	Citations
1	The present and future role of photodynamic therapy in cancer treatment	Brown, SB	Lancet Oncology	2004	1358
2	Endogenous protoporphyrin-IX, A clinically useful photosensitizer for photodynamic therapy	Kennedy, JC	Journal of Photochemistry and Photobiology B-Biology	1992	968
3	Porphyrin and nonporphyrin photosensitizers in oncology: Preclinical and clinical advances inphotodynamictherapy	O’connor, A. E.	Photochemistry and Photobiology	2009	866
4	5-Aminolevulinic acid-based photodynamic therapy - Clinical research and future challenges	Peng, Q.	Cancer	1997	856
5	Photodynamic therapy (PDT): A short review on cellular mechanisms and cancer research applications for PDT	Robertson, CA	Journal of Photochemistry and Photobiology B-Biology	2009	774
6	Photodynamictherapyin oncology - Mechanisms and clinical use	Pass, H. I.	Journal of the National Cancer Institute	1993	653
7	Dye sensitizers for photodynamic therapy	Ormond, AB.	Materials	2013	551
8	Photodynamic therapy in oncology	Triesscheijn, M.	Oncologist	2006	539
9	Non-melanoma skin cancer	Madan, V.	Lancet	2010	537
10	Supramolecular photosensitizers rejuvenate photodynamic therapy	Li, X.	Chemical Society Reviews	2018	534

Abbreviation: ACI, average citation index.

Figure 6 Journal analysis in the field of PDT on skin cancer. Circles with larger diameters represent journals with more publications.

Figure 7 Timeline distribution of the top 20 keywords in the field of PDT on skin cancer.