A Comparison of Clinical Characteristics in Overweight/Obese and Normal Weight Patients with Psoriasis Vulgaris: A Bicentric Retrospective Observational Study

Figures & data

Table 1 Basic Characteristics of the Included Patients

	Total	Overweight/Obesity Group (n=129)	Normal Weight Group (n=79)	p-value
Age, years	41.98 ± 17.02	44.19 ± 15.46	38.37 ± 18.84	0.022
Sex (male/female patients)	161/47	104/25	57/22	0.156
Duration of psoriasis, years	10.00 (2.00, 18.75)	12.00 (4.00, 20.00)	5 (1.00, 14.00)	<0.001
BMI, kg/m^2	25.34 ± 4.51	27.94 ± 3.35	21.08 ± 2.44	-
BSA	11.00 (8.00, 14.00)	11.50 (8.00, 16.00)	10.00 (7.00, 11.25)	0.063
PASI scores	17.10 (12.68, 24.75)	18.90 (14.00, 29.10)	15.90 (10.95, 22.70)	0.032
Smoking, n (%)	76 (36.5%)	51 (39.5%)	25 (31.6%)	0.251
Drinking alcohol, n (%)	23 (11.1%)	14 (10.9%)	9 (11.4%)	0.904
Positive family history of psoriasis, n (%)	36 (17.3%)	24 (18.6%)	12 (15.2%)	0.528
Bunchy hair, n (%)	64 (30.8%)	43 (33.3%)	21 (26.6%)	0.306
Psoriasis nail, n (%)	57 (27.4%)	40 (31.0%)	17 (21.5%)	0.136

Figure 1 Comparison of PSAI scores between the two groups before treatment. *P<0.05.

Figure 2 Linear correlation analysis of BMI and PASI scores.

Table 2 Complications and Hematological Indices

	Total	Overweight/Obesity Group (n = 129)	Normal Weight Group (n = 79)	p-value
Fatty liver, n (%)	91 (51.7%)	78 (67.2%)	13 (21.7%)	<0.001
Hyperlipidemia, n (%)	79 (39.9%)	58 (46.8%)	21 (28.4%)	0.011
Hyperuricemia, n (%)	61 (30.2%)	51 (40.2%)	10 (13.3%)	<0.001
Hypertension, n (%)	46 (22.1%)	34 (26.4%)	12 (15.2%)	0.06
Diabetes, n (%)	29 (13.9%)	20 (15.5%)	9 (11.4%)	0.406
Liver dysfunction, n (%)	29 (14.2%)	23 (18.3%)	6 (7.7%)	0.036
WBC, 10^9/L	7.61 ± 2.64	7.71 ± 2.59	7.46 ± 2.72	0.496
RBC, 10^12/L	4.65 ± 0.52	4.76 ± 0.5	4.46 ± 0.48	0.000
PLT, 10^9/L	230.92 ± 64.65	229.59 ± 68.15	233.12 ± 58.77	0.707
ANC, 10^9/L	4.50 (3.30, 5.90)	4.57 (3.44, 6.14)	4.40 (3.07, 5.34)	0.150
ALC, 10^9/L	1.87 ± 0.65	1.80 ± 0.63	1.98 ± 0.65	0.047
MONO, 10^9/L	0.50 (0.40, 0.60)	0.50 (0.40, 0.60)	0.50 (0.40, 0.60)	0.693
CRP, mg/dL	4.75 (1.87, 10.75)	5.15 (2.43, 9.65)	2.75 (1.54, 11.75)	0.178
IL-6, pg/mL	5.18 ± 4.75	5.42 ± 5.15	4.75 ± 4.03	0.645
ALT, U/L	20.00 (15.00, 30.00)	22.00 (16.00, 34.00)	18.00 (13.00, 25.00)	0.001
AST, U/L	20.00 (16.00, 26.00)	21 (17.00, 27.50)	18.00 (15.25, 25.00)	0.021
TBiL, umol/L	11.44 ± 5.3	11.89 ± 5.38	10.67 ± 5.09	0.113
UA, umol/L	372.57 ± 100.88	396.49 ± 101.45	332.07 ± 86.45	0.000
LPA, g/L	98.00 (46.00, 203.50)	99.0 (48.50, 220.00)	94.50 (44.50, 201.25)	0.822
TG, mmol/L	1.59 ± 1.0	1.65 ± 0.82	1.49 ± 1.24	0.265
TC, mmol/L	4.30 ± 0.86	4.40 ± 0.81	4.14 ± 0.91	0.041
HDL, mmol/L	1.09 ± 0.28	1.06 ± 0.27	1.15 ± 0.31	0.024
LDL, mmol/L	2.60 ± 0.67	2.73 ± 0.64	2.39 ± 0.68	0.000
FPG, mmol/L	5.57 ± 1.73	5.75 ± 1.85	5.25 ± 1.47	0.036
C3, g/L	1.04 ± 0.17	1.07 ± 0.17	0.98 ± 0.17	0.070
C4, g/L	0.24 ± 0.07	0.24 ± 0.07	0.24 ± 0.07	0.882

Abbreviations: WBC, white blood cell; RBC, red blood cell; PLT, platelet; ANC, absolute neutrophil count; ALC, absolute lymphocyte count; MONO, monocyte; CRP, C-reactive protein; IL-6, interleukin 6; ALT, alanine transaminase; AST, aspartate transaminase; TBiL, total bilirubin; UA, uric acid; LPA, lipoprotein A; TG, levels of triglyceride; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HLD, high-density lipoprotein; LDL, low-density lipoprotein; FPG, fasting plasma glucose; C3, Complement 3; C4, Complement 4.