Efficacy, safety, and Pharmacoeconomics of Three Common Strategies for Pediatric Alopecia Areata Patients: A Retrospective Cohort Study

Figures & data

Table 1 Demographic Data and Characteristics of Pediatric AA Patients in Different Groups

	Traditional Group (n=12)	Tofacitinib Group (n=5)	MN Group (n=7)	P-value
Age, mean (SD), years	8.50 (± 3.92)	10.60 (± 3.36)	8.29 (± 3.09)	0.4918
Sex, n (%)
Male	50.00	80.00	57.14
Female	50.00	20.00	42.86
Alopecia areata subtypes, n (%)
Patchy alopecia	100.00	40.00	14.30
Alopecia totalis (AT)	0.00	20.00	14.30
Alopecia universalis (AU)	0.00	0.00	28.55
Ophiasis	0.00	20.00	0.00
Sisaipho	0.00	20.00	14.30
Reticulate alopecia areata	0.00	0.00	28.55
Age of onset, mean (SD), years	7.75 (±3.30)	7.80 (± 3.56)	6.29 (± 2.69)	0.5955
Duration of disease, mean (SD), months	8.33 (±8.51)	32.8 0(±42.46)	23.57 (±22.69)	0.1247
AA medication history, n (%)	0.00	20	57.14
Other medication history	0.00	0.00	28.57
Baseline SALT score, mean (SD)	7.88 (±6.28)	49.30 (±30.00)	54.66 (±40.83)	0.0015
Severity of AA (SALT≥50), n (%)
Severe	0.00	40.00	57.14
Mild & moderate, n (%)	100.00	60.00	42.86
Comorbidity, n (%)	25.00	0.00	85.71

Figure 1 Proportion of efficacy outcomes.

Table 2 Endpoint SALT Score and Recurrence in Each Group

	Traditional Group (n=12)	Tofacitinib Group (n=5)	MN Group (n=7)
Endpoint SALT score, mean (SD)	0.00 (± 0.00)	7.80 (± 8.32)	30.86 (± 39.36)
Recurrence, n (%)	8.33	20.00	28.57

Figure 2 Photographs of a representative patient in the traditional group: panel A-D showed different regions of scalp before and after treatment ((A) top, (B) posterior, (C) left side, (D) right side).

Figure 3 Photographs of a representative patient in the tofacitinib group: panel A-D showed different regions of scalp before and after treatment ((A) top, (B) posterior, (C) left side, (D) right side).

Figure 4 Photographs of a representative patient in the MN group: panel A-C showed different regions of scalp before and after treatment ((A) top, (B) left side, (C) right side).

Table 3 Cost Parameters

Monthly cost of three treatment (CNY)	59.67—225	55	696.00
Frequency of follow-up	Every 8 weeks	Every 4 weeks	Every 2 weeks