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ORIGINAL RESEARCH

Effectiveness of Biologics, Patient-Reported Outcomes, and Clinical Photography in a Subset of Patients with Moderate-to-Severe Psoriasis: Week 12 Results from the Psoriasis Study of Health Outcomes (PSoHO)

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Pages 2971-2983 | Received 21 Jun 2023, Accepted 27 Sep 2023, Published online: 20 Oct 2023

Figures & data

Table 1 Baseline Characteristics of Patients with PsO and Clinical Photography

Figure 1 Percentage of patients achieving improvements in skin and patient-reported outcomes at Week 12. All graphs show upper 95% confidence limits.

Abbreviations: DLQI, Dermatology Life Quality Index; GUS, guselkumab; IXE, ixekizumab; NRS, Numeric Rating Scale; PASI, Psoriasis Area and Severity Index; sPGA, static Physician Global Assessment.
Figure 1 Percentage of patients achieving improvements in skin and patient-reported outcomes at Week 12. All graphs show upper 95% confidence limits.

Figure 2 Proportion of patients showing improvements in PSSD signs and symptoms summary scores at Week 12. PSSD Signs and Symptoms summary score graphs show mean scores and upper and lower 95% confidence limits. PSSD Signs and Symptoms summary scores can range from 0 to 100. Lower scores indicate less severe disease.

Abbreviations: GUS, guselkumab; IXE, ixekizumab; PSSD, Psoriasis Signs and Symptoms Diary.
Figure 2 Proportion of patients showing improvements in PSSD signs and symptoms summary scores at Week 12. PSSD Signs and Symptoms summary score graphs show mean scores and upper and lower 95% confidence limits. PSSD Signs and Symptoms summary scores can range from 0 to 100. Lower scores indicate less severe disease.

Figure 3 Visual treatment effects of IXE at Week 12. (A) Male aged 47 years from Italy; psoriasis for 6 years, bio-naïve, previous systemic conventional therapy, no PsA, diabetes mellitus, overweight, atherosclerosis, dyslipidemia, hypertension and liver disease, initiated IXE as per EMA label at baseline; (B) Female aged 45 from Taiwan; psoriasis for 19 years, bio-experienced, previous systemic conventional therapy, PsA and obesity, switched to IXE as per EMA label at baseline.

Notes: Photographs are subject to Copyright © 2023 Eli Lilly and Company. All rights reserved.
Abbreviations: DLQI, Dermatology Life Quality Index; EMA, European Medicines Agency; IXE, ixekizumab; mNAPSI, Modified Nail Psoriasis Severity Index; NRS, Numeric Rating Scale; PsA, psoriatic arthritis; PASI, Psoriasis Area and Severity Index; PSSD, Psoriasis Signs and Symptoms Diary.
Figure 3 Visual treatment effects of IXE at Week 12. (A) Male aged 47 years from Italy; psoriasis for 6 years, bio-naïve, previous systemic conventional therapy, no PsA, diabetes mellitus, overweight, atherosclerosis, dyslipidemia, hypertension and liver disease, initiated IXE as per EMA label at baseline; (B) Female aged 45 from Taiwan; psoriasis for 19 years, bio-experienced, previous systemic conventional therapy, PsA and obesity, switched to IXE as per EMA label at baseline.

Figure 4 Continued.

Figure 4 Continued.

Figure 4 Visual treatment effects of GUS at Week 12. (A) Male aged 38 from Taiwan; psoriasis for 11.4 years, bio-naïve, previous systemic conventional therapy, disease duration 12 years, no PsA, overweight, dyslipidemia and hypertension. Initiated GUS as per label at baseline. (B) Female aged 45 from Taiwan; psoriasis for 13 years, bio-experienced, previous systemic conventional therapy, disease duration 13 years, PsA. Switched to GUS as per label at baseline.

Notes: Photographs are subject to Copyright © 2023 Eli Lilly and Company. All rights reserved.
Abbreviations: DLQI, Dermatology Life Quality Index; EMA,European Medicines Agency; GUS, guselkumab; mNAPSI, Modified Nail Psoriasis Severity Index; NR, not reported; NRS, Numeric Rating Scale; PsA, psoriatic arthritis; PASI, Psoriasis Area and Severity Index; PSSD, Psoriasis Signs and Symptoms Diary.
Figure 4 Visual treatment effects of GUS at Week 12. (A) Male aged 38 from Taiwan; psoriasis for 11.4 years, bio-naïve, previous systemic conventional therapy, disease duration 12 years, no PsA, overweight, dyslipidemia and hypertension. Initiated GUS as per label at baseline. (B) Female aged 45 from Taiwan; psoriasis for 13 years, bio-experienced, previous systemic conventional therapy, disease duration 13 years, PsA. Switched to GUS as per label at baseline.