Therapeutic Efficacy of Bovine Basic Fibroblast Growth Factor Combined with Ultrapulsed Fractional CO₂ Laser in Acne Scars: Randomized Controlled Trial

Figures & data

Table 1 Table of Clinical Baseline Information

Group	n	Age	Duration of Disease (Years)	BMI (kg/m^2)	Acne Scar Distribution	Gender
					Cheeks/Forehead Chin/Full Face	Male/Female
Control	60	21.7±3.4	2.5±0.7	23.3±1.9	24(40.0)/26(43.3)/10(16.7)	36(60.0)/24(40.0)
Research	60	21.2±3.5	2.4±0.7	23.7±2.0	21(35.0)/25(41.7)/14(23.3)	34(56.7)/26(43.3)
χ^2/t		0.794	0.783	1.123	0.886	0.137
P		0.429	0.436	0.264	0.642	0.711

Abbreviations: n, number of persons; BMI, Body Mass Index.

Table 2 Comparison of Clinical Efficacy

Group	n	Marked Response	Response	Nonresponse	ORR
Control	60	22(36.67)	26(43.33)	12(20.00)	80.00
Research	60	34(56.67)	22(36.67)	4(6.67)	93.33
χ^2					4.615
P					0.032

Abbreviation: n, number of persons.

Figure 1 Comparison of ECCA score and scar base depth (there were 60 cases in each of research and control groups). (A) ECCA score before and after treatment. (B) Scar base depth before and after treatment. #: vs before treatment, P<0.05. &: vs control group, P<0.05.

Figure 2 Comparison of skin condition. (A) The pore value of the skin before and after treatment (there were 60 cases in each of research and control groups). (B) The texture value of the skin before and after treatment. #: vs before treatment, P<0.05. &: vs control group, P<0.05.

Figure 3 Comparison of recovery time (there were 60 cases in each of research and control groups). (A) Comparison of duration of redness. (B) Comparison of scabbing. (C) Comparison of erythema. ^##P<0.01.

Figure 4 Comparison of skin barrier function (there were 60 cases in each of research and control groups). (A) Skin water content before and after treatment. (B) Epidermal oil content before and after treatment. (C) TEWL before and after treatment. #: vs before treatment, P<0.05. &: vs control group, P<0.05.

Table 3 Incidence of Adverse Reactions

Group	n	Pigmentation	Persistent Erythema	Dilated Capillaries	Acne Recurrence	Overall Incidence
Control	60	3(5.00)	6(10.00)	5(8.33)	1(1.67)	25.00
Research	60	2(3.33)	1(1.67)	3(5.00)	0(0.0)	10.00
χ^2						4.675
P						0.031

Abbreviation: n, number of persons.

Data Sharing Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.