Drug-induced skin reactions: a 2-year study

Figures & data

Figure 1 A 25-year-old woman with the diagnosis of acute generalized exanthematous pustulosis following the use of cephalexin.

Figure 2 A 37-year-old woman with clinical manifestation of DRESS syndrome due to phenytoin.

Abbreviation: DRESS, Drug Reaction with Eosinophilia and Systemic Symptoms.

Table 1 Clinical manifestations of cutaneous adverse drug reactions

Clinical feature	n	%	Number of patients histologically confirmed
Acute urticaria	163	52.9	4
Fixed drug eruption	57	18.5	30
Exanthematous eruption	46	14.9	18
Erythema multiforme	7	2.3	7
Acute generalized exanthematous pustulosis	7	2.3	7
Vasculitis	7	2.3	7
Angioedema	7	2.3	–
Erythroderma	4	1.3	4
Stevens–Johnson syndrome	3	1	3
Serum sickness	3	1	0
Exfoliative dermatitis	2	0.6	2
DRESS syndrome	1	0.3	1
Photosensitive dermatitis	1	0.3	1
Total	308	100	84

Abbreviation: DRESS, Drug Reaction with Eosinophilia and Systemic Symptoms.

Figure 3 Causative agents for the three most common types of cutaneous drug reactions: urticaria, fixed drug eruptions, and maculopapular eruptions.

Abbreviation: NSAIDs, non-steroidal anti-inflammatory drugs.