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Original Research

Birch pollen influence the severity of atopic eczema – prospective clinical cohort pilot study and ex vivo penetration study

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Pages 539-548 | Published online: 29 Oct 2015

Figures & data

Table 1 Demographic data

Table 2 Clinical results (source: pollen concentration, SCORAD, subjective parameters of pruritus and sleeplessness)

Figure 1 Pollen concentration (red squares), pruritus (triangle), and subjective assessment of atopic eczema (circles) for sensitized (green lines) and nonsensitized (blue lines) patients.

Figure 1 Pollen concentration (red squares), pruritus (triangle), and subjective assessment of atopic eczema (circles) for sensitized (green lines) and nonsensitized (blue lines) patients.

Table 3 Change in the percentage of irritated skin (all exposed areas, face, nonexposed areas) over time

Figure 2 Specific IgE against birch pollen vs SCORAD.

Notes: (A) Before, (B) at peak of season, and (C) after the birch pollen season show that higher levels of IgE do not correlate with severity.
Abbreviations: SCORAD, Severity Score of Atopic Dermatitis; IgE, immunoglobulin E.
Figure 2 Specific IgE against birch pollen vs SCORAD.

Figure 3 Laser scanning microscopy images of MACS-separated epidermal cells.

Notes: (A and B) Without and (C and D) with fluorescence-labeled pollen allergens; (A and C) transmittance and (B and D) fluorescence mode.
Abbreviation: MAC magnetic activated cell sorting.
Figure 3 Laser scanning microscopy images of MACS-separated epidermal cells.

Table 4 Pollen uptake by CD11c+ epidermal cells from normal skin explants with and without barrier defects

Figure 4 Relative mean values ± standard error for the number of MACS-separated cells with and without fluorescence after pollen allergen application to normal and barrier-disturbed skin.

Abbreviation: MACS, magnetic activated cell sorting.
Figure 4 Relative mean values ± standard error for the number of MACS-separated cells with and without fluorescence after pollen allergen application to normal and barrier-disturbed skin.