Evaluation of a topical treatment for the relief of sensitive skin

Figures & data

Table 1 Mean number of follicles/cm², mean number of comedones/cm², and calculation of comedone score

Test product	Mean follicles/cm^2		Mean comedones/cm ^Citation2		Follicles: comedones		% of follicles showing comedones		Comedone score
	Pre	Post	Pre	Post	Pre	Post	Pre	Post	Pre	Post
No treatment	13.9±1.7	13.4±1.3	0.93±0.29	1.00±0.32	20.8	20.4	6.14±1.68	6.90±2.12	0.25±0.07	0.28±0.09
Acetulan	12.4±1.6	11.8±1.3	0.93±0.06	1.17±0.31*	19.9	12.7*	6.21±1.49	8.30±1.41*	0.25±0.06	0.33±0.06*
Rescue Gel	13.2±1.6	13.0±1.4	0.77±0.10	0.83±0.12	17.5	16.2	5.61±0.45	5.97±0.42	0.22±0.02	0.24±0.02

Notes: The comedone score was determined by follicular biopsies both pretreatment and posttreatment following thrice weekly applications of either no treatment (negative control), Acetulan (positive control), or Rescue Gel for a total of 6 weeks to the backs of volunteers.

* P<0.05 versus no treatment. Data are presented as mean ± SEM.

Abbreviation: Rescue Gel, QV Face Rescue Gel; SEM, standard error of the mean.

Figure 1 Mean fluorescence optical density measured in cultured neonatal human foreskin fibroblasts treated with TGF-β1 (positive control, n=8) or with or without Rescue Gel (1:200) following immunofluorescence staining for collagen type I.

Note: *P<0.001 versus serum free media.
Abbreviations: TGF-β1, transforming growth factor beta 1; Rescue Gel, QV Face Rescue Gel.

Figure 2 Mean fluorescence optical density measured in cultured neonatal human foreskin fibroblasts treated with TGF-β1 (positive control, n=8) or with or without Rescue Gel (1:200) following immunofluorescence staining for collagen type III.

Note: *P<0.0001 versus serum free media.
Abbreviations: TGF-β1, transforming growth factor beta 1; Rescue Gel, QV Face Rescue Gel.

Figure 3 Mean total erythema scores evaluated and scored by visual comparison of subsites on the backs of volunteers.

Notes: Volunteers received either no treatment, 0.5% hydrocortisone cream (positive control), or Rescue Gel applied to the skin at a dose of 4 mg/cm² immediately following a series of UV-simulated irradiations with 1-second increments (three below the MED, one at the MED, and one above the MED), and again 4–5 hours later.*P<0.05 versus no treatment.
Abbreviations: UV, ultraviolet; MED, minimal erythemal dose; Rescue Gel, QV Face Rescue Gel.

Figure 4 Mean percentage reduction in TEWL measurements for Rescue Gel over time (hours).

Notes: The maximum response at each time point is also shown in the figure. *P<0.05 versus t=0.
Abbreviations: TEWL, transepidermal water loss; Rescue Gel, QV Face Rescue Gel.

InamadarACPalitASensitive skin: an overviewIndian J Dermatol Venereol Leprol201379191623254724

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