Reduction of Inflammatory RANTES/CCL5 Serum Levels by Surgery in Patients with Bone Marrow Defects of the Jawbone

Figures & data

Figure 1 BMDJ barely detected on X-Ray (left, area in the red circle), confirmed by CT-scan (right, area in the red circle).

Figure 2 X-Ray of a BMDJ of an implantation site.

Figure 3 Through-transmission alveolar ultrasound screening on a patient presenting a normal X-Ray: confirmation of several BMDJ (red areas).

Figure 4 Post-treatment through-transmission alveolar ultrasound on the same patient confirming normal bone density.

Table 1 Characteristics of Patients

Characteristics	Study Population
Sample size	N = 113
Sex (female; male; %)	62; 38
Age (years; mean ± SD)	47.58 ± 14.06
Relevant dental history
● Tooth extractions per patient	4.88 ± 5.98 (range 0–32)
● Root canal treatment per patient	1.91 ± 2.53 (range 0–11)
Cytokine levels, pre-treatment (755 participants)
● CRP (mg/L)	2.78 ±7.64 (n = 259)
● TNFα (pg/mL)	12.56 ±29.10 (n = 627)
● RANTES/CCL5 (ng/mL)	49.40 ± 42.30 (n = 757)
BMDJ (number/patient)	4.42 ± 2.75 (range 1–10)

Abbreviations: CRP, C-reactive protein; TNF-α, Tumor necrosis factor-α; CCL5, Chemotactic cytokine ligand 5; BMDJ, Bone marrow defect of the jawbone.

Figure 5 RANTES/CCL5 serum concentrations before and after dental therapy.

Abbreviation: BMDJ, Bone marrow defect of the jawbone.

Figure 6 Post-/pre-treatment reduction of RANTES/CCL5 serum concentrations.

Abbreviation: BMDJ, Bone marrow defect of the jawbone.