Cariogram outcome after 90 days of oral treatment with Streptococcus salivarius M18 in children at high risk for dental caries: results of a randomized, controlled study

Figures & data

Figure 1 Scheme of the study.

Figure 2 Graphical representation of Cariogram values (%) calculated using the average value of the items listed.

Abbreviation: Salivarius M18, Streptococcus salivarius M18.

Table 1 Cariogram values (at day 0 and day 90) calculated using the average value of the items listed

Treatment, time period	Actual chance to avoid new cavities (%)	Diet (%)	Bacteria (%)	Susceptibility (%)	Circumstances (%)
Salivarius M18, day 0	20	17	29	23	11
Salivarius M18*, day 90	70	7	7	9	7
Untreated, day 0	20	17	29	23	11
Untreated, day 90	37	11	26	16	10

Note:

* All values of M18, day 90 are significant (P<0.01) vs treatment M18, day 0.

Abbreviation: Salivarius M18, Streptococcus salivarius M18.

Table 2 Characteristics* of the enrolled children

	Salivarius M18-treated group (n=38)	Untreated group (n=38)
Males, n	25	21
Age° of males	11.2±3.2	12.1±2.9
Females, n	13	17
Age° of females	11.5±3.6	11.8±3.8

Notes:

* Nonsignificant differences between groups; °age expressed in years ± standard deviation.

Abbreviation: Salivarius M18, Streptococcus salivarius M18.

Table 3 Global Cariogram outcome at day 0 and day 90

	Salivarius M18-treated group (n=38)	Untreated group (n=38)
Day 0**	15.9±2.6 (16)	16.3±2.9 (16)
Day 90**	11.1±2.0 (11)*	14.4±3.2 (14)
Δ % vs day 0	30.2	11.7

Notes:

* P<0.01 vs day 0;

** data expressed as mean ± standard deviation (median).

Abbreviation: Salivarius M18, Streptococcus salivarius M18.

Table 4 Cariogram: outcome of individual parameters in the salivarius M18-treated group (n=38)

	Day 0*	Day 90*	P
Caries experience	2.7±0.5 (3)	2.7±0.5 (3)	ns
Related diseases	0.0±0.2 (0)	0.1±0.2 (0)	ns
Diet, content	1.9±1.0 (2)	1.4±0.7 (1)	<0.05
Diet, frequency	1.4±0.8 (1)	1.2±0.5 (1)	<0.05
Plaque amount	2.0±0.8 (2)	1.0±0.6 (1)	<0.01
Mutans streptococci	2.7±0.5 (3)	0.7±0.8 (0)	<0.01
Fluoride program	2.4±0.7 (2)	1.8±0.5 (2)	<0.01
Saliva secretion	1.7±0.9 (2)	1.2±1.1 (1)	<0.05
Buffer capacity	0.0±0.2 (0)	0.0±0.0 (0)	<0.05
Clinical judgment	1.1±0.4 (1)	1.0±0.2 (1)	ns

Note:

* Data expressed as mean ± standard deviation (median).

Abbreviations: ns, not significant; salivarius M18, Streptococcus salivarius M18.

Table 5 Cariogram: outcome of individual parameters in the untreated group (n=38)

	Day 0*	Day 90*	P
Caries experience	2.8±0.5 (3)	2.8±0.6 (3)	ns
Related diseases	0.1±0.2 (0)	0.2±0.2 (0)	ns
Diet, content	2.0±1.0 (2)	1.3±0.4 (1)	<0.01
Diet, frequency	1.3±0.8 (1)	1.1±0.7 (1)	<0.05
Plaque amount	2.0±0.9 (2)	2.1±0.7 (2)	ns
Mutans streptococci	2.6±0.5 (3)	2.5±0.6 (3)	ns
Fluoride program	2.3±0.7 (2)	1.6±0.7 (1)	<0.01
Saliva secretion	1.8±0.9 (2)	1.4±1.2 (1)	<0.05
Buffer capacity	0.2±0.2 (0)	0.2±0.2 (0)	ns
Clinical judgment	1.2±0.4 (1)	1.2±0.1 (1)	ns

Note:

* Data expressed as mean ± standard deviation (median).

Abbreviation: ns, not significant.

Table 6 Tolerability, compliance, and side effects in children (n=38) treated for 90 days by oral route with Streptococcus salivarius M18 as reported by themselves and/or parents and established by dentists responsible for the study

	Tolerability	Compliance	Side effects
Very good	n=30	n=32	None
Good	n=5	n=6	None
Acceptable	n=3	n=0	None
Unacceptable	n=0	n=0	None