Why targeting the microbiome is not so successful: can randomness overcome the adaptation that occurs following gut manipulation?

Figures & data

Table 1 Factors that impact studies of fecal microbiota transplantation and their clinical efficacy

Host related parameters	Gender
	Age
	Diet
	Body weight
	Concomitant disease and medications
Microbiome-related parameters	Being a highly dynamic and constantly changing organ
	Rapid adaptation to manipulation
Environmental factors	The response to exposomes: environmental factors that the host interacts with
	Household contacts
Testing	Software used for analyzing data
	Exploring feces vs scraping the bowel wall itself for microbiome analysis