Association of IFNL3 rs12979860 polymorphism with HCV-related hepatocellular carcinoma susceptibility in a Chinese population

Figures & data

Table 1 Characteristics of previous studies on the association of IFNL3 rs12979860 polymorphism and HCC risk

Study	Year	HCV genotype	Risk factor associated with HCC	Reference
Buivydiene et al.	2018	GT1 GT2 GT3	rs12979860 CC genotype	^Citation30
Suo et al.	2013	ND	rs12979860 TT genotype	^Citation20
Attallah et al.	2018	GT4	rs12979860 TT genotype	^Citation21
Chang et al.	2015	GT1 non-GT1	rs12979860 CT+TT genotype	^Citation22
Lee et al.	2015	GT1 non-GT1	rs12979860 CT+TT genotype	^Citation23
Ibrahim et al.	2016	ND	rs12979860 CT+TT genotype	^Citation24
Chang et al.	2018	GT1 non-GT1	rs12979860 CT+TT genotype	^Citation25
Fabris et al.	2011	ND	rs12979860 T allele	^Citation26
El-Awady et al.	2012	GT4a	rs12979860 T allele	^Citation27
Eurich et al.	2012	GT1b non-GT1b	rs12979860 T allele	^Citation28
Zhang et al.	2016	ND	rs12979860 T allele	^Citation29
Agúndez et al.	2012	GT1 non-GT1	No association	^Citation31
Bochud et al.	2012	GT1 GT2 GT3 GT4	No association	^Citation32
Joshita et al.	2012	GT1 GT2	No association	^Citation33
Miura et al.	2012	GT1b	No association	^Citation34
Akkiz et al.	2014	ND	No association	^Citation35
Zekri et al.	2014	ND	No association	^Citation36

Abbreviations: IFNL3, interferon lambda-3; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; GT, genotype; ND, not determined.

Table 2 Demographic and clinical characteristics of the study population

Characteristics	HCC patients N=62 (%)	CHC patients N=95 (%)	P-value
Gender			0.467
Male	35(56.45%)	48(50.53%)
Female	27(43.55%)	47(49.47%)
Age (years)			0.118
≤60	30(48.39%)	58(61.05%)
>60	32(52.61%)	37(38.95%)
BMI			0.329
<24	33(53.23%)	43(45.26%)
≥24	29(46.77%)	52(54.74%)
Duration of HCV infection (years)			0.825
≤20	25(40.32%)	40(42.11%)
>20	37(59.68%)	55(57.89%)
HCV genotype			0.416
1b	51(82.26%)	73(76.84%)
Non-1b	11(17.74%)	22(23.16%)

Abbreviations: HCC, hepatocellular carcinoma; CHC, chronic hepatitis C; BMI, body mass index; HCV, hepatitis C virus.

Figure 1 Genotype and allele frequencies of IFNL3 rs12979860 in CHC and HCC groups.

Notes: (A) Genotype frequencies of IFNL3 rs12979860 in CHC and HCC groups; (B) comparison of genotype proportions between CHC group and HCC group; (C) allele frequencies of IFNL3 rs12979860 in CHC and HCC groups; (D) comparison of allele proportions between CHC group and HCC group.
Abbreviations: CHC, chronic hepatitis C; HCC, hepatocellular carcinoma; IFNL3, interferon lambda-3.

Figure 2 Association between IFNL3 rs12979860 polymorphism and HCC risk under different genetic models.

Notes: (A) Genetic model of allele frequency; (B) genetic model of general genotype; (C) dominant model; (D) recessive model.
Abbreviations: HCC, hepatocellular carcinoma; CHC, chronic hepatitis C; IFNL3, interferon lambda-3.

Figure 3 Association between IFNL3 rs12979860 polymorphism and HCC risk stratified by genotype.

Notes: (A) HCV genotype 1b group; (B) HCV genotype non-1b group.
Abbreviations: HCC, hepatocellular carcinoma; CHC, chronic hepatitis C; IFNL3, interferon lambda-3; HCV, hepatitis C virus.

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