Eosinophilic esophagitis incidence in New Zealand: high but not increasing

Figures & data

Table 1 Characteristics of patients with eosinophilic esophagitis

	Children (age <16)			Adults (age ≥16)			Overall
	n		%	n		%	n		%
Total number	9		5.9	143		94.1	152		100
Male sex	6			100			106		69.7
Female sex	3			43			46		30.3
Mean age at diagnosis							42.2 [age range 0–85]
Ethnicity (more than one ethnic group per person could have been specified)
	Children (age <16) n=9			Adults (age ≥16) n=143			Overall n=152
	n	%		n	%		n	%
European†	8	88.9		122	‡90.4		130	‡90.3
Maori	☥			7	‡5.2		7	‡4.9
Asian	☥			3	‡2.2		4	‡2.8
Pacific Island	☥			3	‡2.2		3	‡2.1
Other	☥			2	‡1.5		2	‡1.4
Unspecified	☥			8			8

Notes: ^†Either “NZ European” or “other European”. ^‡Valid percentage (not including unspecified cases). ^☥Numbers not published due to confidentiality concerns.

Table 2 Indication for endoscopy (patients could present with >1 indication)

	Children (age <16) n=9		Adults (age ≥16) n=143		Overall n=152
	n	%	n	%	n	%
Dysphagia	4	44.4	109	76.2	113	74.3
Food bolus impaction	0		29	20.3	29	19.1
Abdominal/chest pain	3	33.3	22	15.4	25	16.4
Heartburn	0		17	11.9	17	11.2
Nausea/vomiting	3	33.3	7	4.9	10	6.6

Table 3 Endoscopic features recorded in endoscopy report (>1 endoscopic feature could be present on endoscopy)

	Children (age <16) n=9		Adults (age ≥16) n=143		Overall n=152
	n	%	n	%	n	%
No features recorded	3	33.3	45	31.5	48	31.6
Ringed esophagus	3	33.3	88	61.5	91	59.9
Furrows	5	55.6	56	39.4	61	40.4
Strictures	1	11.1	19	13.3	20	13.2
White exudates	2	22.2	9	6.3	11	7.2
Crepe paper esophagus	0		4	2.8	4	2.6

Table 4 Histologic features recorded in the biopsy report (>1 histological feature could be present on the biopsy report)

	Children (age <16) n=9		Adults (age ≥16) n=143		Overall n=152
	n	%	n	%	n	%
Basal cell hyperplasia	5	55.6	68	47.6	73	48
Elongated vascular papillae	1	11.1	52	36.4	53	34.9
Spongiosis	2	22.2	34	23.8	36	23.7
Eosinophilic mirco abscesses	2	22.2	17	11.9	19	12.5
Intraepithelial edema	1	11.1	22	15.4	23	15.1

Table 5 Location of the biopsy in which a histological diagnosis was made

	Overall n=152
	n	%
Proximal ± distal esophageal biopsy	85	55.9
Distal esophageal biopsy only (ie not proximal)	38	25
Locations of biopsies not reported	29	19.1

Table 6 The incidence rates (per 100,000 person years, 95% CI) by year and age group

Year	Population	Children (aged <16)			Adults (aged ≥16)			All patients with EoE
		n	Incidence per 100,000	95% CI	n	Incidence per 100,000	95% CI	n	Incidence per 100,000	95% CI
2011	433,350	2	2.33	[0.26,8.4]	29	7.16	[4.95,10.03]	31	*8.35	[5.59,11.99]
2012	434,720	1	1.17	[0.02,6.51]	37	8.74	[6.27,11.87]	38	*10.59	[7.46,14.6]
2013	435,930	3	3.53	[0.71,10.32]	18	4.82	[3.06,7.24]	21	5.13	[3.04,8.11]
2014	440,030	1	1.18	[0.02,6.58]	34	7.96	[5.63,10.94]	35	*9.57	[6.62,13.4]
2015	444,190	2	2.38	[0.27,8.59]	25	6.08	[4.09,8.72]	27	6.94	[4.49,10.25]

Note: *Is significantly different from the rate for the young age group.