Newer agents for Helicobacter pylori eradication

Figures & data

Table 1 New molecules with H. pylori activity

Molecule	MIC90 value (mg/L)	pH activity	Cla-R/ Met-R
Arylthiazole derivative 44	0.0065	NA	NA/NA
Benzimidazole derivatives
Y-754	0.025	5.5	NA/NA
BAS-118	0.013	NA	Yes/yes
I-valnemulin	0.0125–0.5	NA	Yes/yes
Mupirocin	0.12–0.25	5.4	NA/NA
Polycyclic compound	0.2–0.39	NA	NA/NA
Pyloricidin (A, B, and C)	0.013	NA	NA/NA
Rifampin	0.032–2	NA	Yes/yes

Notes: MIC₉₀: minimal inhibitory concentration; Cla-R: efficacy towards clarithromycin resistant strains; Met-R: efficacy towards metronidazole resistant strains.

Abbreviation: NA, not available.

Table 2 Some plant extracts with potential anti-H. pylori activity in vitro

Plant source	Source or molecule	MIC90 (mg/L)
Barringtonia acutangola	Leaf	25
Cassia grandis	Leaf	50
Cleome viscosa	Leaf	50
Cycas siamensis	Leaf	100
Hypericum perforatum	L. Hyperforin	15.6–31.2
Hyptis fasciculata	Cirsilineol/cirsimaritin	3.2–6.3
Kaempferia galanga	Rhizome	25
Litsea elliptica	Leaf	100
Maleleuca quinquenervia	Leaf	100
Mallotus philippinensis	Rottlerin	3.12–6.25
Myristica fragrans	Aril	12.5
Myristica fragrans	Leaf	50
Pistacia lentiscus	Triterpenic acids	0.139
Pouzolzia pentandra	Leaf	100
Syzygium aromaticum	Leaf	50
Vitis vinifera	Resveratrol	6–12.5
Xanthium brasilicum	Xanthanolide	13.2–250
Zingiber officinale	Rhizome	0.78–12.5

Abbreviation: MIC₉₀, minimal inhibitory concentration.