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Clinical and Experimental Gastroenterology Volume 15, 2022 - Issue
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Case Report

Alkaline Phosphatase Pathophysiology with Emphasis on the Seldom-Discussed Role of Defective Elimination in Unexplained Elevations of Serum ALP – A Case Report and Literature Review

Michael D Levitt1 Medicine Service, Veterans Affairs Medical Center, Minneapolis, MN, 55417, USA
,
Sophie M Hapak2 Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA
&
David G Levitt3 Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, 55455, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3757-4716
ORCID Icon
Pages 41-49 | Published online: 15 Mar 2022

Figures & data

Figure 1 Chronology of serum ALP measurement during the course of the patient’s illness. Electrophoretic analysis of a serum sample obtained near the time of the peak level showed that the ALP was comprised of 51% liver, 23% bone and 26% macrohepatic isoforms, with no detectable placental or intestinal ALP isoforms. The arrow indicates the time that voriconazole treatment was initiated.

Figure 1 Chronology of serum ALP measurement during the course of the patient’s illness. Electrophoretic analysis of a serum sample obtained near the time of the peak level showed that the ALP was comprised of 51% liver, 23% bone and 26% macrohepatic isoforms, with no detectable placental or intestinal ALP isoforms. The arrow indicates the time that voriconazole treatment was initiated.

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