Outcomes in patients with nonerosive reflux disease treated with a proton pump inhibitor and alginic acid ± glycyrrhetinic acid and anthocyanosides

Figures & data

Table 1 Personal and baseline characteristics of subjects (n = 29 per group)

Variable	Group A	Group B	P
Age (years)	52.9 ± 15.2	47.3 ± 12.6	0.1358
Height (cm)	164.3 ± 24.4	167.1 ± 19.5	0.6317
Weight (kg)	71.9 ± 11.0	71.6 ± 13.8	0.9249
Treatment duration (days)	65.7 ± 9.0	63.1 ± 4.0	0.1734
Males	11	15	0.2909
Females	18	14	0.3167

Note: Results are presented as the mean ± standard deviation.

Table 2 Symptom scores for chest pain

Group	n	Baseline	MC 2	MC 3	MC 4	MC 5
A	24	4.08 ± 2.50	1.96 ± 1.88	1.13 ± 1.33	1.08 ± 1.50	1.08 ± 1.84
B	22	5.06 ± 2.32	3.82 ± 2.11	4.23 ± 1.48	3.64 ± 1.99	3.59 ± 2.24
P value		NS	<0.05	<0.05	<0.05	<0.05

Note: Results are presented as the mean ± standard deviation.

Abbreviations: MC, medical check; NS, not statistically significant.

Table 3 Symptom scores for heartburn

Group	n	Baseline	MC 2	MC 3	MC 4	MC 5
A	24	5.83 ± 1.99	1.96 ± 1.68	1.21 ± 1.10	0.96 ± 1.00	1.50 ± 1.32
B	27	5.93 ± 2.38	3.41 ± 2.56	3.26 ± 2.16	3.41 ± 1.95	3.19 ± 2.09
P value		NS	<0.05	<0.05	<0.05	<0.05

Note: Results are presented as the mean ± standard deviation.

Abbreviations: MC, medical check; NS, not statistically significant.

Table 4 Symptom scores for abdominal swelling

Group	n	Baseline	MC 2	MC 3	MC 4	MC 5
A	24	5.75 ± 2.57	3.08 ± 2.26	2.21 ± 1.96	2.25 ± 1.54	2.21 ± 1.74
B	24	6.71 ± 2.22	5.21 ± 2.19	5.33 ± 1.88	5.04 ± 1.68	4.54 ± 1.91
P value		NS	<0.05	<0.05	<0.05	<0.05

Note: Results are presented as the mean ± standard deviation.

Abbreviations: MC, medical check; NS, not statistically significant.

Table 5 Symptom scores for regurgitation

Group	n	Baseline	MC 2	MC 3	MC 4	MC 5
A	15	5.67 ± 2.26	2.00 ± 1.77	1.20 ± 1.42	0.80 ± 1.15	0.60 ± 0.91
B	19	4.00 ± 2.89	1.16 ± 1.71	1.95 ± 2.46	2.95 ± 2.76	2.89 ± 2.85
P value		NS	NS	NS	<0.05	<0.05

Note: Results are presented as the mean ± standard deviation.

Abbreviations: MC, medical check; NS, not statistically significant.

Table 6 Symptom scores for hoarseness

Group	n	Baseline	MC 2	MC 3	MC 4	MC 5
A	11	4.27 ± 2.41	1.91 ± 1.76	1.45 ± 1.51	1.09 ± 1.30	0.91 ± 1.14
B	14	4.50 ± 2.85	2.57 ± 3.01	2.57 ± 2.44	3.00 ± 2.83	3.21 ± 2.86
P value		NS	NS	NS	<0.05	<0.05

Note: Results are presented as the mean ± standard deviation.

Abbreviations: MC, medical check; NS, not statistically significant.

Table 7 Symptom scores for cough

Group	n	Baseline	MC 2	MC 3	MC 4	MC 5
A	15	2.80 ± 2.34	1.13 ± 1.77	0.93 ± 1.36	1.13 ± 1.64	0.47 ± 1.13
B	17	2.76 ± 2.99	1.59 ± 2.27	1.65 ± 2.15	1.94 ± 2.54	2.00 ± 2.85
P value		NS	NS	NS	NS	<0.05

Note: Results are presented as the mean ± standard deviation.

Abbreviations: MC, medical check; NS, not statistically significant.

Table 8 Symptom scores for throat pain

Group	n	Baseline	MC 2	MC 3	MC 4	MC 5
A	14	4.00 ± 3.09	1.43 ± 1.50	0.64 ± 0.93	1.14 ± 1.66	0.36 ± 0.63
B	14	3.71 ± 2.20	1.79 ± 2.22	1.57 ± 1.87	1.79 ± 2.19	2.07 ± 2.09
P value		NS	NS	NS	NS	NS

Note: Results are presented as the mean ± standard deviation.

Abbreviations: MC, medical check; NS, not statistically significant.

Table 9 Mean global outcome

Group	Baseline	MC 2	MC 3	MC 4	MC 5
A	20.9	8.8	5.5	5.5	5.0
B	23.7	14.2	14.9	15.4	15.1
Wilcoxon S	974.5	1063.5	1206.5	1211.5	1201.0
P value	0.0637	0.0012	<0.0001	<0.0001	<0.0001

Note: Results are presented as the mean ± standard deviation.

Abbreviation: MC, medical check.

Table 10 Tolerability outcome

Tolerability	Group A (n)	Group B (n)	P
Poor	0	2	NS
Fair	7	10	NS
Good	11	17	NS
Excellent	11	0	0.002

Abbreviation: NS, not statistically significant.

Table 11 Results for compliance

Compliance	Group A (n)	Group B (n)	P
Fair	3	1	NS
Good	17	19	NS
Excellent	9	9	NS

Abbreviation: NS, not statistically significant.