Lack of effect of methotrexate in budesonide-refractory collagenous colitis

Figures & data

Table 1 Patient characteristics

Patient	Sex	Age (years)	Date of diagnosis	Comorbidity	Previous treatment for CC
1	F	47	06/2006	Anxiety, depression, pustulosis palmoplantaris, bile acid malabsorption	lop, chol, bud
2	F	44	03/2010	Raynaud’s phenomenon, asthma	lop, chol, bud
3	M	74	02/2006	Whipple operation in 2009 due to benign pancreatic tumor, bile acid malabsorption	lop, chol, bud, mes, pred
4	F	49	03/2001	None	lop, chol, bud, aza
5	M	77	06/2009	Prostatic cancer treated with radiotherapy in 2005	lop, chol, bud, pred
6	F	54	10/2006	None	lop, chol, bud
7	F	62	05/2003	Hypothyreosis, cholecystectomy	lop, chol, mes, pred, bud, ab
8	F	72	04/2006	Breast cancer, asthma, hyperthyreosis	lop, chol, mes, bud, ab
9	F	65	11/1997	Hypertension Billroth ii operation due to bleeding gastric ulcer in 2006	lop, chol, mes, sulf, ab, bud

Abbreviations: ab, antibiotics; aza, azathioprine; bud, budesonide; CC, collagenous colitis; chol, cholestyramine; lop, loperamide; mes, mesalazine; pred, prednisolone; sulf, sulfasalazine.

Table 2 Results of methotrexate (MTX) treatment

Patient	Duration of MTX treatment (weeks)	Mean number of stools/watery stools per day at baseline	Mean number of stools/watery stools per day after 6 weeks or at withdrawal	Mean number of stools/watery stools per day after 12 weeks	Effect of MTX
1	3	6.5/3.0	6.0/4.0		Discontinued due to AE (nausea, mood swings)
2	12	8.0/8.0	9.0/9.0	6.5/6.5	No clinical effect
3	12	7.0/7.0	4.0/4.0	9.0/7.0	No clinical effect
4	12	3.5/1.0	6.5/6.5	7.0/7.0	No clinical effect
5	6	4.5/4.5	3.5/3.5		Discontinued due to AE (nausea, conjunctivitis, fatigue)
6	12	3.5/1.5	1.0/0.0	3.5/2.0	No clinical effect
7	4	8.0/4.0	6.0/3.0		Discontinued due to AE (more diarrhea, nausea, chills)
8	3	5/1	4.5/1.5		Discontinued due to AE (allergic reaction = intense erythema and edema in the eyes and face)
9	12	8/8	7.5/7.5	6/6	No clinical effect

Abbreviation: AE, adverse effect.