Association between juxtapapillary diverticulum and acute cholangitis determined using laboratory data

Figures & data

Table 1 Comparison of laboratory data between patients with and without juxtapapillary diverticulum

	Without juxtapapillary diverticulum (n =98)		With juxtapapillary diverticulum (n =37)		P-value
	Mean	95% CI	Mean	95% CI
Age, years	69.2	67.2–71.2	69.0	65.7–72.3	0.8989
WBC	7,391	6,551–8,232	8,308	6,940–9,676	0.2610
CRP	2.62	1.57–3.67	4.12	2.39–5.85	0.1448
T-Bil	1.54	1.04–2.05	1.81	0.99–2.63	0.5821
ALP	447	365–529	626	495–757	0.0237
AST	119	77–160	124	57–192	0.8873
ALT	118	84–151	140	85–194	0.4962
γ-GTP	249	181–316	341	231–451	0.1575

Note: P-values were determined by Wilcoxon’s signed-rank test.

Abbreviations: CI, confidence interval; WBC, white blood cell; CRP, C-reactive protein; T-Bil, total bilirubin; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GTP, glutamyl transpeptidase.

Table 2 Comparison of laboratory data between patients with acute cholangitis with and without juxtapapillary diverticulum

	Without juxtapapillary diverticulum (n =27)		With juxtapapillary diverticulum (n =26)		P-value
	Mean	95% CI	Mean	95% CI
Age	69.4	65.6–73.3	68.8	64.8–72.3	0.5989
WBC	10,122	8,075–12,169	9,080	6,995–11,166	0.3502
CRP	6.19	3.65–8.73	4.83	2.19–7.47	0.6207
T-Bil	2.93	1.59–4.27	2.03	0.67–3.40	0.8033
ALP	639	475–804	713	548–877	0.9854
AST	209	123–295	123	36–211	0.2332
ALT	204	131–276	149	78–220	0.5783
γ-GTP	350	227–474	382	256–508	0.5591

Note: P-values were determined by Wilcoxon’s signed-rank test.

Abbreviations: CI, confidence interval; WBC, white blood cell; CRP, C-reactive protein; T-Bil, total bilirubin; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GTP, glutamyl transpeptidase.

Table 3 Correlation between juxtapapillary diverticulum and acute cholangitis or bile-duct dilatation

	Acute cholangitis (P<0.0001)		Bile-duct dilatation (P=0.0107)		Total
	−	+	−	+
Juxtapapillary diverticulum
−	72	27	59	40	99
+	11	26	13	24	37
Total	83	53	72	64	136

Note: P-values were determined by χ² test.

Table 4 Correlation between acute cholangitis and bile-duct dilatation

	Bile-duct dilatation		Total
	−	+
Acute cholangitis
−	53	30	83
+	19	34	53
Total	72	64	136

Note: P=0.0013 (χ² test).

Table 5 Correlation between juxtapapillary diverticulum and symptoms of acute cholangitis

	Abdominal pain (P=0.2117)		Total	Fever (P=0.6854)		Total	Jaundice (P=0.8928)		Total
	−	+		−	+		−	+
Juxtapapillary diverticulum
−	8	19		12	15		14	13	27
+	4	22		13	13		13	13	26
Total	24	45		25	28		27	26	69

Note: P-values were determined by χ² test.

Table 6 Logistic regression analysis of patients with acute cholangitis without juxtapapillary diverticulum

	χ^2	OR	95% CI of OR	P-value
WBC	1.61	1.0001084	0.999709–1.000055	0.2052
CRP	4.48	1.176696	0.721717–0.979098	0.0342
T-Bil	1.49	1.1781629	0.580052–1.057499	0.2226
ALP	1.1×10^−6	0.9999953	0.997434–1.002703	0.9972
AST	0.19	1.001254	0.991369–1.004106	0.6660
ALT	0.27	1.0018022	0.991558–1.00594	0.6040
γ-GTP	0.03	1.0002375	0.991558–1.002736	0.8616

Note: P-values were determined by logistic regression analysis.

Abbreviations: OR, odds ratio; CI, confidence interval; WBC, white blood cell; CRP, C-reactive protein; T-Bil, total bilirubin; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GTP, glutamyl transpeptidase.

Table 7 Logistic regression analysis of patient with acute cholangitis with diverticulum

	χ^2	OR	95% CI of OR	P-value
WBC	2.62	1.000497	0.998739–0.999954	0.0251
CRP	2.98	0.6993023	0.987904–2.373463	0.0582
T-Bil	1.17	1.77331172	0.168276–1.456388	0.2509
ALP	3.10	1.0044708	0.988934–0.999331	0.0150
AST	3.61	0.989096	1.000797–1.024472	0.0336
ALT	0.28	1.0033479	0.982806–1.008615	0.5874
γ-GTP	0.08	1.0005787	0.994856–1.003876	0.7741

Note: P-values were determined by logistic regression analysis.

Abbreviations: OR, odds ratio; CI, confidence interval; WBC, white blood cell; CRP, C-reactive protein; T-Bil, total bilirubin; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GTP, glutamyl transpeptidase.