Figures & data
Figure 1 Delayed elevations of circulating E2 and ERα expression after PH were observed in the ORC and OVX mice.
Abbreviations: E2, estradiol; ERα, estrogen receptor α; PH, partial hepatectomy; ORC, orchiectomy; OVX, ovariectomy; SEM, standard error of the mean.
![Figure 1 Delayed elevations of circulating E2 and ERα expression after PH were observed in the ORC and OVX mice.](/cms/asset/6100b451-ea5e-44db-8c9d-daf06149d366/dceg_a_80212_f0001_b.jpg)
Figure 2 The estrous cycle regulated E2 concentration and hepatocyte proliferation.
Abbreviations: E2, estradiol; BrdU, bromodeoxyuridine; SEM, standard error of the mean.
![Figure 2 The estrous cycle regulated E2 concentration and hepatocyte proliferation.](/cms/asset/3bfbba8b-88f4-4df8-9088-95a8fad16b94/dceg_a_80212_f0002_b.jpg)
Figure 3 SERM administration regulated hepatocyte proliferation.
Abbreviations: SERM, selective estrogen receptor modulator; E2, estradiol; ICI, ICI182780; BrdU, bromodeoxyuridine; GPR, G protein-coupled receptor; ERα, estrogen receptor α; ERβ, estrogen receptor β; SEM, standard error of the mean; DPN, 2,3-bis(4-hydroxyphenyl)propionitrile; PPT, 4,4′,4′-(4-propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol.
![Figure 3 SERM administration regulated hepatocyte proliferation.](/cms/asset/e721dfd9-c38a-4e5d-845c-43d7cde8b71c/dceg_a_80212_f0003_b.jpg)
Figure 4 PH induced ERα expression in the hepatocyte of periportal area.
Abbreviations: PH, partial hepatectomy; ERα, estrogen receptor α; RT-PCR, reverse transcription polymerase chain reaction; ISH, in situ hybridization; OVX, ovariectomy; E2, estradiol; HPRT, hypoxanthine-guanine phosphoribosyltransferase.
![Figure 4 PH induced ERα expression in the hepatocyte of periportal area.](/cms/asset/dc462779-8604-4d7e-a37a-aa509d754e5a/dceg_a_80212_f0004_b.jpg)
Figure 5 OVX did not affect liver weight recovery after PH, and the hepatocyte proliferations were delayed.
Abbreviations: OVX, ovariectomy; PH, partial hepatectomy; BrdU-IHC, bromodeoxyuridine immunohistochemistry; SEM, standard error of the mean; NS, nonsignificant; OPE, operation.
![Figure 5 OVX did not affect liver weight recovery after PH, and the hepatocyte proliferations were delayed.](/cms/asset/275fbfec-a945-493a-9495-6e84363fd17d/dceg_a_80212_f0005_b.jpg)
Figure 6 Model of hepatocyte proliferation in female mice.
Abbreviations: PH, partial hepatectomy; E2, estradiol; ERα, estrogen receptor α; LR, liver regeneration.
![Figure 6 Model of hepatocyte proliferation in female mice.](/cms/asset/32e199f3-2d66-45b3-8ba2-5a44cdd69096/dceg_a_80212_f0006_b.jpg)