Difficult-to-heal wounds of mixed arterial/venous and venous etiology: a cost-effectiveness analysis of extracellular matrix

Figures & data

Figure 1 Weeks to healing across treatment groups.

Notes: A Student’s t-test was used to compare outcomes.
Abbreviations: ECM, extracellular matrix; SC, standard of care.

Table 1 Unit cost

Resource	Quantity	Cost
HOPPS rate low cost skin substitute (C5271)a	1 visit/wk	$430.12
Physician rate skin substitute application (CPT 15271)	1 visit/wk	$87.24
OPPS rate hospital outpatient clinic visit (G0463)a	3 visits/wk	$294.18
Physician rate evaluation and management visit level 2 (CPT 99212)	3 visits/wk	$77.34

Note:

a Healthcare Common Procedure Coding System (HCPCS) stated.

Abbreviations: CPT, Current Procedural Terminology; HOPPS, Hospital Outpatient Prospective Payment System; OPPS, Outpatient Prospective Payment System; wk, week.

Table 2 Population demographics

Variable	ECM (n=25)	SC (n=23)	P-value
Male, %	52	48	NSS
Ulcer size, mean, cm^2	23.5	25.2	NSS
Ulcer duration, mean, wk	7.2	6.9	NSS

Note: Data were analyzed using Analysis of Variance (ANOVA) for multiple comparisons (SPSS 10 for Windows), with the significance level set at P<0.05. Additionally, Male % significance was tested via a chi-square and Ulcer size and Ulcer duration were tested via a student’s t-test.

Abbreviations: ECM, extracellular matrix; NSS, not statistically significant; SC, standard of care; wk, week.

Figure 2 Comparison of closed-wound weeks between a cellular/tissue-derived product treatment in relation to SC for the management of venous leg ulcers.

Abbreviations: ECM, extracellular matrix; SC, standard of care.

Figure 3 Cost-effectiveness acceptability curve by treatment.

Abbreviations: ECM, extracellular matrix; SC, standard of care.