Healthcare resource consumption and cost of care among patients with polycystic kidney disease in Italy

Figures & data

Table 1 Baseline demographic and clinical characteristics of the study population stratified according to PKD subtype and dialysis status at the index date

	Non-dialyzed (n, %)	Dialyzed (n, %)	Total (n, %)
All patients with PKD diagnosis	1,030 (91.7)	93 (8.3)	1,123 (100)
Age (mean ± SD)	57.5±25.2	60.1±14.8	57.7±24.5
Male	631 (61.3)	31 (62.9)	695 (61.9)
Autosomal dominant	84 (66.7)	42 (33.3)	126 (100.0)
Age (mean ± SD)	43.1±24.7	58.8±13.6	48.3±22.8
Male	52 (61.9)	24 (57.1)	76 (60.3)
Autosomal recessive	12 (92.3)	NI	13 (100.0)
Age (mean ± SD)	37.8±35.9	–	41.6±35.5
Male	7 (58.3)	NI	8 (61.5)
Genotype unspecified	159 (85.5)	27 (14.5)	186 (100.0)
Age (mean ± SD)	61.4±24.9	58.9±13.3	61.0±23.5
Male	94 (59.1)	20 (74.1)	114 (61.3)
Other	775 (97.1)	23 (2.9)	798 (100.0)
Age (mean ± SD)	58.6±24.5	62.9±19.0	58.7±24.4
Male	478 (61.7)	19 (83.0)	497 (62.3)

Notes: All included patients were classified as “dialyzed patients” based on the presence of at least one recording of outpatient specialist services related to dialysis (codes 38.95, 39.95, 54.93, 54.98, and 97.29.1) during or after the index date. Patients were also classified according to the discharge diagnosis, after hospitalization for PKD, as suffering from ADPKD, ARPKD, or unspecified genotype if they had the ICD-9-CM codes: 753.13, 753.14, and 753.12, respectively. Patients who did not have any of the ICD-9-CM codes listed above are defined as “other.”

Abbreviations: ADPKD, autosomal-dominant polycystic kidney disease; ARPKD, autosomal-recessive polycystic kidney disease; ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification; PKD, polycystic kidney disease; SD, standard deviation; NI, not issuable.

Table 2 Healthcare consumption (in terms of the average annual number of pharmaceutical prescriptions, ambulatory care services, and hospital admissions) during the follow-up period stratified according to PKD subtype

	Autosomal dominant		Autosomal recessive		Genotype unspecified		Other
	Mean	± SD	Mean	± SD	Mean	± SD	Mean	± SD
Pharmaceutical prescriptions
Non-dialyzed	14.5	16.0	10.1	10.1	16.6	14.8	15.1	14.0
Dialyzed	27.7	15.3	NI	–	31.6	20.4	29.0	16.8
Total	18.8	16.9	13.1	13.0	18.8	16.6	15.5	14.3
Ambulatory care services
Non-dialyzed	5.1	11.1	2.0	3.7	6.6	8.7	5.1	6.7
Dialyzed	28.2	13.2	NI	–	29.8	13.9	26.7	14.2
Total	12.7	16.1	4.7	8.7	10.0	12.6	5.7	7.9
Hospital admissions
Non-dialyzed	0.8	1.3	1.4	1.8	0.9	1.5	0.8	1.3
Dialyzed	1.2	1.7	NI	–	1.6	1.2	1.6	1.5
Total	0.9	1.4	1.2	1.7	1.0	1.5	0.9	1.3

Notes: All included patients were classified as “dialyzed patients” based on the presence of at least one recording of outpatient specialist services related to dialysis (codes 38.95, 39.95, 54.93, 54.98, and 97.29.1) during or after the index date. Patients were also classified according to the discharge diagnosis, after hospitalization for PKD, as suffering from ADPKD, ARPKD, or unspecified genotype if they had the ICD-9-CM codes: 753.13, 753.14, and 753.12, respectively. Patients who did not have any of the ICD-9-CM codes listed above are defined as “other”.

Abbreviations: ADPKD, autosomal-dominant polycystic kidney disease; ARPKD, autosomal-recessive polycystic kidney disease; ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification; PKD, polycystic kidney disease; SD, standard deviations; NI, not issuable.

Figure 1 Mean annual cost per PKD patient during the follow-up period. Costs are reported in euros (€).

Notes: All included patients were classified as “dialyzed patients” based on the presence of at least one record of outpatient specialist services related to dialysis (codes 38.95, 39.95, 54.93, 54.98, and 97.29.1) during or after the index date. Patients were also classified according to the discharge diagnosis, after hospitalization for PKD, as suffering from ADPKD, ARPKD, or unspecified genotype if they had the ICD-9-CM codes: 753.13, 753.14, and 753.12, respectively. Patients who did not have any of the ICD-9-CM codes listed above are defined as “other.”
Abbreviation: ADPKD, autosomal-dominant polycystic kidney disease; ARPKD, autosomal-recessive polycystic kidney disease; ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification; PKD, polycystic kidney disease.

Figure 2 Mean annual cost per patient during the follow-up period stratified according to PKD subtypes (ADPKD, ARPKD, unspecified genotype, or other). Costs are reported in euros (€).

Notes: All included patients were classified as “dialyzed patients” based on the presence of at least one record of outpatient specialist services related to dialysis (codes 38.95, 39.95, 54.93, 54.98, and 97.29.1) during or after the index date. Patients were also classified according to the discharge diagnosis, after hospitalization for PKD, as suffering from ADPKD, ARPKD, or unspecified genotype if they had the ICD-9-CM codes: 753.13, 753.14, and 753.12, respectively. Patients who did not have any of the ICD-9-CM codes listed above are defined as “other.”
Abbreviations: ADPKD, autosomal-dominant polycystic kidney disease; ARPKD, autosomal-recessive polycystic kidney disease; ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification; NI, not issuable.