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Original Research

Indirect costs associated with premature mortality among those with veno-occlusive disease/sinusoidal obstruction syndrome with multiorgan dysfunction post-hematopoietic stem-cell-transplant

, &
Pages 13-22 | Published online: 17 Dec 2018

Figures & data

Figure 1 Schematic representation of the model.

Notes: Model inputs (in blue boxes) included annual incidence of HSCT by age, VOD/SOS by graft type (allogeneic and autologous), and VOD/SOS with MOD among HSCT patients. In turn, these values were inputs for the calculation of excess mortality associated with VOD/SOS with MOD (model outputs in purple boxes). The calculated excess mortality rates in each age-group were used to determine the cost of lost work productivity, which was calculated based on employment rates and mean salaries by age.
Abbreviations: alloHSCT, allogeneic HSCT; autoHSCT, autologous HSCT; HSCT, hematopoietic stem-cell transplant; MOD, multiorgan dysfunction; SOS, sinusoidal obstruction syndrome; VOD, veno-occlusive disease.
Figure 1 Schematic representation of the model.

Table 1 Allogeneic and autologous HSCT and mortality by age-group (preretirement population)

Table 2 General population average annual salary, employment rate, and reduction in life expectancy for HSCT patients by age-group

Table 3 Deterministic sensitivity analysis modeling variables of work-productivity loss due to premature death from VOD/SOS with MOD vs HSCT survivors without VOD/SOS

Figure 2 Annual number of excess deaths in the total population across all ages (including patients aged >65 years).

Notes: Calculated as number of deaths among HSCT patients with VOD/SOS and MOD, based on published incidence and mortality rates (),Citation3,Citation11,Citation12 minus the number of deaths among patients with VOD/SOS and MOD that were attributed to other (non-VOD/SOS and MOD) causes (eg, primary disease, other complications, and natural causes). Interim calculation by age and type of transplant (N=361). aAutoHSCT and alloHSCT combined may not add up to total due to rounding.
Abbreviations: alloHSCT, allogeneic HSCT; autoHSCT, autologous HSCT; HSCT, hematopoietic SCT; MOD, multiorgan dysfunction; SOS, sinusoidal obstruction syndrome; VOD, veno-occlusive disease.
Figure 2 Annual number of excess deaths in the total population across all ages (including patients aged >65 years).

Table 4 Lost work-productivity years and indirect costs (2014 US$) due to excess deaths from VOD/SOS with MOD vs HSCT survivors by age-group (preretirement population)

Figure 3 Total work-productivity loss associated with premature death due to VOD/SOS with MOD by age and graft type compared to HSCT survivors.

Abbreviations: alloHSCT, allogeneic HSCT; autoHSCT, autologous HSCT; HSCT, hematopoietic SCT; MOD, multiorgan dysfunction; SOS, sinusoidal obstruction syndrome; VOD, veno-occlusive disease.
Figure 3 Total work-productivity loss associated with premature death due to VOD/SOS with MOD by age and graft type compared to HSCT survivors.

Figure 4 Deterministic sensitivity analysis: total work-productivity loss due to VOD/SOS with MOD compared with HSCT survivors.

Abbreviations: HSCT, hematopoietic stem-cell transplant; MOD, multiorgan dysfunction; SOS, sinusoidal obstruction syndrome; VOD, veno-occlusive disease.
Figure 4 Deterministic sensitivity analysis: total work-productivity loss due to VOD/SOS with MOD compared with HSCT survivors.