New Perspective to Improve Care of Patients with Infected Diabetic Foot Ulcer: Early Economic Impact of the Use of Photodynamic Therapy with RLP068 (Based) System

Figures & data

Table 1 Reimbursements Associated with the Management of DFIs

Code	Description	Tariff
Standard of Care
86.22	Removal of wound, infection or burn	20.40 €
86.27	Curettage	20.40 €
86.28	Medication of wound, infection or burn	10.08 €
89.70	Specialist Visit	20.66 €
96.59	Other wound irrigation	3.87 €
Total		75.41 €
Standard of Care + PDT-RLP068 system
89.01	Specialist Visit	20.66 €
86.28	Medication of wound, infection or burn	10.08 €
96.59.6	Advanced medication because of infection*	125.12 €
Total		155.86 €

Note: *Code and tariff retrieved from Lombardia Region.

Abbreviation: PDT, photodynamic therapy.

Table 2 Percentage of Patients Treated with the PDT-RLP068 System + SoC in the Period 2020–2024 and Estimated Number of Patients Treated Considering the Addition of the PDT-RLP068 System to SoC or with Only SoC

	2020	2021	2022	2023	2024
Percentage of patients treated with PDT-RLP068 system + SoC	0.3%	0.8%	1.6%	2.4%	3%
Estimated number of DFIs patients treated with PDT-RLP068 based system + SoC	592	1,597	3,233	4,910	6,213
Estimated number of DFIs patients treated with SoC	196,683	198,063	198,856	199,654	200,871

Abbreviations: DFIs, diabetic foot infected ulcers; PDT, photodynamic therapy; SoC, standard of care.

Table 3 Results from the Base Case Cost-Effectiveness Analysis of PDT-RLP068 System

	Outpatient Setting
Additional Days with Clinical Target Achieved with the Use of PDT-RLP068 System+ SoC	Cost Difference	ICER
None	644 €	SoC is less costly
7 days (reduction of time: 10%)	493 €	70.4 €
14 days (reduction of time: 20%)	342 €	24.4 €
21 days (reduction of time: 30%)	191 €	9.1 €
28 days (reduction of time: 40%)	40 €	1.4 €
35 days (reduction of time: 50%)	−111 €	−3.2 €

Abbreviations: ICER, incremental cost-effectiveness ratio; PDT, photodynamic therapy; SoC, standard of care.

Table 4 Results from the Scenario Analysis

	Inpatient Setting
Additional Days with Clinical Target Achieved with the Use of PDT-RLP068 System+ SoC	Cost Difference	ICER
None	0 €	No differences
7 days (reduction of time: 10%)	−472 €	−7.5 €
14 days (reduction of time: 20%)	−944 €	−13.5 €
21 days (reduction of time: 30%)	−1,416 €	−18.4 €
28 days (reduction of time: 40%)	−1,888 €	−22.5 €
35 days (reduction of time: 50%)	−2,360 €	−25.9 €

Abbreviations: ICER, incremental cost-effectiveness ratio; PDT, photodynamic therapy.

Figure 1 Results from the probabilistic sensitivity analysis.

Figure 2 Outpatient setting scenario: cumulative 5-year budget impact related to the addition of the PDT-RLP068 system to SoC.

Figure 3 Inpatient setting scenario: cumulative 5-year budget impact related to the addition of the PDT-RLP068 system to SoC.