Changes in the Penetration Rate of Biosimilar Infliximab Within Japan Using a Japanese Claims Database

Figures & data

Table 1 Patient Characteristics

		Reference (n=8950)	Biosimilar (n=785)
Age, mean (SD)		44.6 (17.65)	52.9 (17.10)
0–9 years		20 (0.2%)	0 (0.0%)
10–20 years		628 (7.0%)	16 (2.0%)
20–29 years		1487 (16.6%)	85 (10.8%)
30–39 years		1616 (18.1%)	85 (10.8%)
40–49 years		1769 (19.8%)	134 (17.1%)
50–59 years		1291 (14.4%)	130 (16.6%)
60–69 years		1267 (14.2%)	184 (23.4%)
70–79 years		731 (8.2%)	133 (16.9%)
≥80 years		139 (1.6%)	18 (2.3%)
Male		5006 (55.9%)	344 (43.8%)
Receiving subsidy for intractable disease		5718 (63.9%)	240 (30.6%)
Target disease diagnosis	RA	2631 (29.4%)	442 (56.3%)
	CD	3619 (40.4%)	178 (22.7%)
	UC	2851 (31.9%)	172 (21.9%)
	Ps	680 (7.6%)	55 (7.0%)
Multiple target disease		798 (8.9%)	61 (7.8%)
Comorbidity	IP	463 (5.2%)	66 (8.4%)
	COPD	34 (0.4%)	4 (0.5%)
	DM	22 (0.2%)	8 (1.0%)
	Hypertension	11 (0.1%)	0 (0.0%)
Switch to other biologics		1484 (16.6%)	107 (13.6%)
Switch to JAK inhibitors		65 (0.7%)	13 (1.7%)
Hospitalization		3829 (42.8%)	305 (38.9%)

Abbreviations: SD, standard deviation; RA, rheumatoid arthritis; CD, Crohn’s disease; UC, ulcerative colitis; Ps, psoriasis; IP, interstitial pneumonia; COPD, chronic obstructive pulmonary disease; DM, diabetes mellitus; JAK Janus kinase.

Table 2 Number of Patients Receiving the Reference Infliximab or Its Biosimilar for Target Disease Diagnosis (Whole, with or without Subsidy for Intractable Disease) Throughout the Study Period from 2014 to 2018

Target Disease	With or without Subsidy	All (n)	Reference (n)	Biosimilar (n)	Biosimilar Penetration Rate
RA	Whole	3073	2631	442	14.4%
	With	508	487	21	4.1%
	Without	2565	2144	421	16.4%
CD	Whole	3797	3619	178	4.7%
	With	3241	3122	119	3.7%
	Without	556	497	59	10.6%
UC	Whole	3023	2851	172	5.7%
	With	2622	2504	118	4.5%
	Without	401	347	54	13.5%
Ps	Whole	735	680	55	7.5%
	With	136	130	6	4.4%
	Without	599	550	49	8.2%

Abbreviations: RA, rheumatoid arthritis; CD, Crohn’s disease; UC, ulcerative colitis; Ps, psoriasis.

Figure 1 Patient flow chart. *Target diseases: RA (ICD10 Code: M05, M06), UC (ICD10 Code: K51), CD (ICD10 Code: K50), and Ps (ICD10 Code: L40).

Abbreviations: MDV, Medical Data Vision; RA, rheumatoid arthritis; CD, Crohn’s disease; UC, ulcerative colitis; Ps, psoriasis; ICD, International Classification of Diseases; N, number of patients.

Figure 2 The penetration rate of biosimilar infliximab by fiscal year.

Abbreviations: Ref, reference product; BS, biosimilar; N, number of patients; RA, rheumatoid arthritis; CD, Crohn’s disease; UC, ulcerative colitis; Ps, psoriasis.