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Original Research

Patient-Reported Outcomes for Migraine in the US and Europe: Burden Associated with Multiple Preventive Treatment Failures

Pages 647-660 | Published online: 14 Jul 2021

Figures & data

Table 1 Physician-Reported Patient Characteristics According to Number of Lines of Preventive Treatments Ever Received

Table 2 Clinical Characteristics According to Number of Lines of Preventive Treatments Ever Received

Figure 1 Migraine-Specific Quality of Life Questionnaire (MSQ) domain scores according to number of lines of preventive treatments ever received. The number of patients with data varied by group size (see ). Across all three groups, the response rate for this instrument was 98% (2748 of 2798) of patients who completed a patient self-completion form.

Notes: ***P<0.0001 across groups; **P<0.01 (ANOVA test). Higher scores indicate better health status. Trends were consistent across regions (US + EU).
Abbreviation: SD, standard deviation.
Figure 1 Migraine-Specific Quality of Life Questionnaire (MSQ) domain scores according to number of lines of preventive treatments ever received. The number of patients with data varied by group size (see Table 1). Across all three groups, the response rate for this instrument was 98% (2748 of 2798) of patients who completed a patient self-completion form.

Table 3 MIDAS Items According to Number of Lines of Preventive Treatments Ever Received

Figure 2 Migraine Disability Assessment Scale (MIDAS) scores according to number of lines of preventive treatments ever received. Higher scores indicate greater disability. The number of patients with data varied by group size (see ). Across all groups, the response rate for this instrument was 83% (2316 of 2798) of patients who completed a patient self-completion form. Trends were consistent across regions (US + EU).

Notes: P<0.0001 across all treatment groups and all severity categories (chi-squared test).
Figure 2 Migraine Disability Assessment Scale (MIDAS) scores according to number of lines of preventive treatments ever received. Higher scores indicate greater disability. The number of patients with data varied by group size (see Table 1). Across all groups, the response rate for this instrument was 83% (2316 of 2798) of patients who completed a patient self-completion form. Trends were consistent across regions (US + EU).

Figure 3 EQ-5D-5L scores according to number of lines of migraine preventive treatments (A) mean EQ-5D 5-level score cross-walked to 3-level score and (B) mean VAS score. Patients completed the 5-level EQ-5D; scores were cross-walked to the 3-level version.Citation25,Citation26 The number of patients with data varied by group size; the response rate for this instrument was 99% (2763 of 2798 patients who completed a patient self-completion form).

Notes: ***P<0.0001 across groups (ANOVA test).
Abbreviations: EQ-5D-5L, EuroQol 5-Level  5-Dimension questionnaire; SD, standard deviation; VAS, visual analog scale.
Figure 3 EQ-5D-5L scores according to number of lines of migraine preventive treatments (A) mean EQ-5D 5-level score cross-walked to 3-level score and (B) mean VAS score. Patients completed the 5-level EQ-5D; scores were cross-walked to the 3-level version.Citation25,Citation26 The number of patients with data varied by group size; the response rate for this instrument was 99% (2763 of 2798 patients who completed a patient self-completion form).

Figure 4 WPAI in the overall patient population according to number of lines of migraine preventive treatments. The number of patients with data varied by group size; the response rate for this instrument was 54% for work productivity impairment (patients in employment only; 1440 of 2798 patients who completed a PSC) and 94% for activity impairment (2633 of 2798 patients who completed a patient self-completion form).

Notes: ***P<0.001; **P<0.01; *P<0.05 across groups (ANOVA test).
Abbreviations: SD, standard deviation; WPAI, Work Productivity and Activity Impairment.
Figure 4 WPAI in the overall patient population according to number of lines of migraine preventive treatments. The number of patients with data varied by group size; the response rate for this instrument was 54% for work productivity impairment (patients in employment only; 1440 of 2798 patients who completed a PSC) and 94% for activity impairment (2633 of 2798 patients who completed a patient self-completion form).