Clinical and Economic Value of a Biosimilar Portfolio to Stakeholders: An Integrative Literature Review

Figures & data

Table 1 Embase/MEDLINE Search Strategy

Topic	Search	String	Hits
Portfolio	S1	TI,AB (portfolio) OR TI,AB (product portfolio) OR TI,AB (R&D portfolio) OR TI,AB (drug portfolio) OR TI,AB (drug development portfolio) OR TI,AB (drug pipeline portfolio) OR TI,AB (pharmaceutical portfolio) OR TI,AB (biopharmaceutical portfolio) OR TI,AB (manufacturer portfolio) OR TI,AB (portfolio strategy) OR TI,AB (portfolio contract) OR TI,AB (portfolio based contract) OR TI,AB (portfolio agreement)	15,172
Value	S2	TI,AB (value*) OR TI,AB(“value of”) OR TI,AB(“perceived value of”) OR TI,AB(“perceived value”) OR TI,AB(“value proposition”) OR TI,AB(“value demonstration”) OR TI,AB (tender*) OR TI,AB (benefit*) OR TI,AB(“benefit of”)	6,973,616
Combine portfolio and value	S3	S1 AND S2	142,364
Study design	S4	TI,AB (clinical AND (trial or study or studies)) OR TI,AB(“RCT”) OR TI,AB((singl* OR doubl* OR treb* or tripl*) NEAR/1 (blind[*3] OR mask[*3])) OR TI,AB (placebo[*1]) OR TI,AB (random* NEAR/2 allocated) OR EMB.EXACT.EXPLODE(“Clinical trial”) OR EMB.EXACT(“Controlled clinical trial”) OR EMB.EXACT(“Randomized controlled trial”) OR EMB.EXACT(“Single blind procedure”) OR EMB.EXACT(“Double blind procedure”) OR EMB.EXACT(“Crossover procedure”) OR RTYPE(“Clinical trial, Phase I”) OR RTYPE(“Clinical trial, Phase II”) OR RTYPE(“Clinical trial, Phase III”) OR RTYPE(“Clinical trial, Phase IV”) OR RTYPE(“Controlled clinical trial”) OR RTYPE(“Multicenter study”) OR RTYPE(“Clinical trial”)	7,898,395
Publication type	S5	TI,AB (case NEAR/1 (stud* OR report)) OR EMB.EXACT(“Case study”) OR EMB.EXACT(“Abstract report” OR “Letter”) OR RTYPE(“Case reports”) OR RTYPE(“Letter”) OR RTYPE(“Historical article”) OR RTYPE(“Editorial”) OR RTYPE(“Note”)	8,696,821
Combine study design	S6	S4 AND S5	8,696,821
Combine portfolio, value, and study design	S7	S3 NOT S6	452,206
Time limit	S8	S7 AND pd(>20091231)	1,618
English limit	S9	S8 AND LA (English)	1,577*

Note: *Duplicates between Embase and MEDLINE removed from the results count.

Abbreviations: Embase, Excerpta Medica Database; MEDLINE, Medical Literature Analysis and Retrieval System Online.

Table 2 Eligibility Criteria

Criteria	Description
Population	Key stakeholders, such as patients, clinicians, pharmacy staff, nursing staff, and the institution/finance staff
Intervention	No restriction
Comparator	No restriction
Outcome	Value of a biosimilar portfolio
Study design	Observational studies Systematic literature reviews Non-systematic or narrative reviews
Other	Studies published in 2010 to present English language

Figure 1 PRISMA flow diagram for study selection.

Figure 2 Hypothetical biosimilar portfolio value to specific stakeholders.

Figure 3 Hypothetical conceptual framework for composition of biosimilar portfolio value.