Esophageal cancer: comparative effectiveness of treatment options

Figures & data

Table 1 Studies of definitive RT alone vs definitive CRT for esophageal cancer

References	N		RT dose (Gy)		Chemotherapy	Median OS (months)		5-year OS (%)		P-value
	RT	CRT	RT	CRT		RT	CRT	RT	CRT
Cooper et al^Citation12	62	61	64	50	DDP + 5-FU	–	–	0	26
Al-Sarraf et al^Citation13	62	61	64	50	DDP + 5-FU	9.3	14.1	0	27	<0.0001
Herskovic et al^Citation14	60	61	64	50	DDP + 5-FU	8.9	12.5	–	–	<0.001
Smith et al^Citation15	60	59	40+S; 60	40+S; 60	MMC + 5-FU	9.2	14.8	7	9	<0.05
Smit et al^Citation16	177	110	60	50.4	DDP based	–	–	–	–	0.071

Abbreviations: CRT, chemoradiotherapy; DDP, cisplatin; 5-FU, fluorouracil; OS, overall survival; RT, radiotherapy; S, surgery; MMC, mitomycin.

Table 2 Randomized trials of neoadjuvant CRT vs surgery alone for esophageal cancer

References	N		RT dose	CT	pCR(%)	DFS(%)			OS (%)
	CRT	S				CRT	S	P-value	CRT	S	P-value
Tepper et al^Citation11	30	26	50.4 Gy/1.8 Gy/28f	DDP + 5-FU	33.3	–	–	–	5 years: 39	5 years: 16	<0.05
Bosset et al^Citation25	143	139	37 Gy/3.7 Gy/10f	DPP	26	–	–	0.003	–	–	0.78
Urba et al^Citation26	50	50	45 Gy/1.5 Gy/30f	DDP + 5-FU	28	3 years: 28	3 years: 16	0.16	3 years: 30	3 years: 16	0.15
				+ VCR
Lee et al^Citation27	51	50	45.6 Gy/1.2 Gy/38f	DDP + 5-FU	43	2 years: 49	2 years: 51	0.93	2 years: 55	2 years: 57	0.69
Burmeister et al^Citation28	128	128	35 Gy/2.33 Gy/15f	DDP + 5-FU	16	–	–	–	–	–	0.57
Lv et al^Citation29	80	80	40 Gy/2 Gy/20f	DDP + PTX		–	–	–	5 years: 43.5	5 years: 34	<0.05
van Hagen et al^Citation30	178	188	41.4 Gy/1.8 Gy/23f	CBP + PTX	29	5 years: 44	5 years: 27	<0.001	5 years: 47	5 years: 33	<0.05
Shapiro et al^Citation36	178	188	41.4 Gy/1.8 Gy/23f	CBP + PTX		–	–	–	–	–	0.003
Apinop et al^Citation31	35	34	–	DPP + 5-FU	27	–	–	–	–	–	>0.05
Le Prise et al^Citation32	41	45	20 Gy/2 Gy/I0f	DPP + 5-FU		–	–	–	–	–	>0.05
walsh et al^Citation33	58	55	40 Gy/2.67 Gy/15f	DPP + 5-FU	25	–	–	–	3 years: 32	3 years: 6	0.01
Natsugoe et al^Citation34	22	23	40 Gy/2 Gy/20f	DPP + 5-FU		–	–	–	5 years: 57	5 years: 41	>0.05
Ariga et al^Citation35	51	48	60 Gy/2 Gy/30f	DPP + 5-FU		–	–	–	5 years: 75.7	5 years: 51	0.0169

Abbreviations: CBP, carboplatin; CRT, chemoradiotherapy; CT, chemotherapy; DDP, cisplatin; DFS, disease-free survival; 5-FU, fluorouracil; OS, overall survival; pCR, pathological complete response rate; PTX, paclitaxel; RT, radiotherapy; S, surgery; VCR, vinblastine.

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