Long noncoding RNAs and Alzheimer’s disease

Figures & data

Table 1 Dysregulated lncRNAs in Alzheimer’s disease

lncRNAs	Target	Role	References
BACE1-AS↑	Upregulation BACE1 mRNA stability	Aβ↑	^Citation16
51A↑	Downregulating SORL1 variant A	Aβ↑	^Citation59,Citation61
17A↑	Impairing the GABA B signaling	Aβ↑, Aβx-42/Aβx-40↑	^Citation62,Citation63
NDM29↑	Promoting the cleavage activity of BACE and γ-secretase	Aβ↑, Aβx-42/Aβx-40↑	^Citation12
BC200 ↑/↓	Targeting at eIF4A to decouple ATP hydrolysis	Modulators of local protein synthesis to maintain the long-term synaptic plasticity	^Citation65
NAT-Rad18 ↑	Controlling the expression of DNA repair protein Rad18	Making the neuron more sensitive to apoptosis	^Citation68

Notes: The arrows next to lncRNAs indicates up/down regulation. The arrows next to Aβ indicates up/down expression.

Abbreviations: Aβ, amyloid β peptide; BACE1, β-site APP cleaving enzyme-1; BC200, brain cytoplasmic 200 RNA; GABA, gamma-aminobutyric acid; eIF4A, eukaryotic initiation factor 4A; lncRNAs, long noncoding RNAs; mRNA, messenger RNA; NDM29, neuroblastoma differentiation marker 29; SORL1, sortilin-related receptor gene; ATP, adenosine triphosphate.

Figure 1 Dysregulated lncRNAs in AD.

Notes: BACE1-AS, 17A, 51A, and NDM29 directly or indirectly increase Aβ formation and/or the Aβx-42/Aβx-40 ratio. BC200 modulates local protein synthesis to maintain long-term synaptic plasticity. NAT-Rad18 is implicated in apoptosis. The arrows next to Aβ indicates up/down expression.
Abbreviations: Aβ, amyloid β peptide; AD, Alzheimer’s disease; BACE1, β-site APP cleaving enzyme-1; BC200, brain cytoplasmic 200 RNA; eIF4A, eukaryotic initiation factor 4A; lncRNAs, long noncoding RNAs; NDM29, neuroblastoma differentiation marker 29; SORL1, sortilin-related receptor gene; mRNA, messenger RNA.

FaghihiMAModarresiFKhalilAMExpression of a noncoding RNA is elevated in Alzheimer’s disease and drives rapid feed-forward regulation of beta-secretaseNat Med200814772373018587408

 PubMed Web of Science ®Google Scholar

CiarloEMassoneSPennaIAn intronic ncRNA-dependent regulation of SORL1 expression affecting Abeta formation is upregulated in post-mortem Alzheimer’s disease brain samplesDis Model Mech20136242443322996644

 PubMed Web of Science ®Google Scholar

MaQLGalaskoDRRingmanJMReduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluidArch Neurol200966444845719364929

 PubMedGoogle Scholar

MassoneSVassalloIFiorinoG17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer diseaseNeurobiol Dis201141230831720888417

 PubMed Web of Science ®Google Scholar

GavazzoPVassalliMCostaDPaganoANovel ncRNAs transcribed by Pol III and elucidation of their functional relevance by biophysical approachesFront Cell Neurosci2013720324223537

 PubMed Web of Science ®Google Scholar

MassoneSCiarloEVellaSNDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid beta secretionBiochim Biophys Acta2012182371170117722580042

 PubMed Web of Science ®Google Scholar

LinDPestovaTVHellenCUTiedgeHTranslational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanismMol Cell Biol20082893008301918316401

 PubMed Web of Science ®Google Scholar

IacoangeliABianchiRTiedgeHRegulatory RNAs in brain function and disordersBrain Res20101338364720307503

 PubMed Web of Science ®Google Scholar