Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment

Figures & data

Figure 1 Mean air conduction hearing threshold.

Note: Error bars represent standard deviations (SDs).

Table 1 Sequences of the PCR primers for BAK1, BCL2, and ACTB

Gene	GenBank accession number	Amplicon size (bp)	Reverse primer	Forward primer
BAK1	NM_001188.3	120	CAA ACA GGC TGG TGG CAA TC	TCA TCG GGG ACG ACA TCA AC
BCL2	NM_000633.2	129	CAG CCA GGA GAA ATC AAA CAG AGG	ATC GCC CTG TGG ATG ACT GAG
ACTB	NM_001101.3	131	GTA GTT TCG TGG ATG CCA CA	TCC CTG GAG AAG AGC TAC G

Abbreviation: PCR, polymerase chain reaction.

Figure 2 Gene expression of BAK1 in peripheral blood samples from Iranian patients with ARHI and healthy subjects.

Notes: The difference between the two groups is statistically significant (U=484, P=0.008). The box plots show the median (solid line across the box).
Abbreviation: ARHI, age-related hearing impairment.

Figure 3 Gene expression of BCL2 in peripheral blood samples from Iranian patients with ARHI and healthy subjects.

Notes: Difference between the two groups is statistically significant (U=548, P=0.04).
Abbreviation: ARHI, age-related hearing impairment.

Figure 4 The BAK1/BCL2 gene expression ratios of Iranian patients with ARHI and healthy subjects. The difference between the two groups is statistically significant (U=544, P=0.039).

Abbreviation: ARHI, age-related hearing impairment.