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Review

Colorectal cancer development and advances in screening

Pages 967-976 | Published online: 19 Jul 2016

Figures & data

Figure 1 CRC development and screening methods.

Notes: (A) Histological changes of CRC; (B) acquired genetic changes of CRC; (C) effective screening tests for CRC. The temporal development of CRC is indicated from left to right in each panel. Includes methylation of BRAF, KRAS, BMP3, and NDRG4 genes. Data from O’Brien et al.Citation28
Abbreviations: CRC, colorectal cancer; CIMP, CpG island methylator phenotype; CT, computed tomography; FOBT, fecal occult blood test; FIT, fecal immunochemical test; MSI, microsatellite instability; sDNA, stool DNA.
Figure 1 CRC development and screening methods.

Figure 2 Polyps.

Notes: (A) Flat, serrated polyp. (B) Pedunculated polyp. Photos courtesy of Louis M. Wong Kee Song, MD, Professor of Medicine, Division of Gastroenterology, Mayo Clinic.
Figure 2 Polyps.

Table 1 CRC screening tests