Application of 18F-FDG PET/CT combined with carbohydrate antigen 19-9 for differentiating pancreatic carcinoma from chronic mass-forming pancreatitis in Chinese elderly

Figures & data

Table 1 Characteristics of study participants

Characteristics	Study participants
Age, mean ± SD	69±7.1
Sex, n (%)	38 (63.3%)
BMI, mean ± SD	24±5.8
PC, n (%)	40 (66.7%)
CMFP, n (%)	20 (33.3%)
Diabetes mellitus, n (%)	9 (15%)

Abbreviations: BMI, body mass index; PC, pancreatic carcinoma; CMFP, chronic mass-forming pancreatitis; SD, standard deviation.

Table 2 Application of 18F-FDG PET/CT and CA19-9 in differentially diagnosing PC from CMFP

Characteristics	Status	PC, n	CMFP, n	Sensitivity	Specificity	Accuracy
18F-FDG uptake	Increased	38	8	95%	60%	83.3%
	Normal	2	12
CA19-9 levels	Elevated	35	8	87.5%	60%	78.3%
	Normal	5	12
18F-FDG uptake and CA19-9 levels	Both	36	2	90%	90%	90%
	Other	4	18

Abbreviations: CA19-9, carbohydrate antigen 19-9; PC, pancreatic carcinoma; CMFP, chronic mass-forming pancreatitis.

Figure 1 Images of a male participant, 69 years.

Notes: Computed tomography showed that there was a suspicious lesion in his pancreas. His carbohydrate antigen 19-9 level was 51.68. 18F-FDG PET/CT showed that there was no lesion with increased 18F-FDG uptake in his pancreas. Finally, he was diagnosed with chronic mass-forming pancreatitis. (A) Pancreatic head lesion in computed tomography; (B) pancreatic head lesion in 18F-FDG PET/CT; (C) pancreatic duct dilatation in computed tomography; and (D) pancreatic duct dilatation in 18F-FDG PET/CT.

Abbreviations: PET, positron emission tomography; CT, computed tomography.

Figure 2 Images of a female participant, 66 years.

Notes: Computed tomography showed that there was a suspicious lesion in her pancreas. Her carbohydrate antigen 19-9 level was 1015. 18F-FDG PET/CT showed that there was a lesion with increased 18F-FDG uptake (standardized uptake value maximum =6.34) in her pancreas. Finally, she was diagnosed with pancreatic carcinoma. (A) Coronal view of images obtained by 18F-FDG PET; (B) horizontal view of images obtained by 18F-FDG PET; (C) horizontal view of images obtained by CT; (D) and horizontal view of images obtained by 18F-FDG PET/CT.
Abbreviations: PET, positron emission tomography; CT, computed tomography.

Figure 3 Scatter plot for participants with chronic mass-forming pancreatitis between standardized uptake value maximum and carbohydrate antigen 19-9 levels.

Figure 4 Scatter plot for participants with pancreatic carcinoma between standardized uptake value maximum and carbohydrate antigen 19-9 levels.