Efficacy and safety outcomes of fractional flow reserve in guiding clinical therapy of non-ST-segment elevation myocardial infarction compared with angiography alone in elderly Chinese patients

Figures & data

Table 1 Baseline characteristics of patients in clinical therapy guided by FFR or angiography alone

Characteristics	FFR-guided group (n=110)	Angiography-guided group (n=110)	P-value
Age, years, mean ± SD	70±3.7	70±3.4	0.267
Men, n (%)	75 (68.2)	78 (70.9)	0.660
Smoking, n (%)			0.908
Current	29 (26.4)	31 (28.2)
Former	41 (37.3)	38 (34.5)
Never	40 (36.4)	41 (37.3)
Previous MI, n (%)	24 (21.8)	23 (20.9)	0.869
Heart failure, n (%)	2 (1.8)	1 (0.9)	1.000
Hypertension, n (%)	81 (73.6)	83 (75.5)	0.757
Diabetes mellitus, n (%)	40 (36.4)	36 (32.7)	0.571
Hyperlipidemia, n (%)	90 (81.8)	93 (84.5)	0.589
Peak troponin levels, n (%)
>×5 upper limit of normal	87 (79.1)	82 (74.6)	0.424
>×10 upper limit of normal	69 (62.7)	64 (58.2)	0.491
Procedural characteristics, n (%)
Radial artery access	95 (86.4)	98 (89.1)	0.538
Aspirin	110 (100.0)	110 (100.0)
Clopidogrel	89 (80.9)	86 (78.2)	0.616
Ticagrelor	21 (19.1)	24 (21.8)	0.616
Statin	103 (93.6)	105 (95.5)	0.553
Beta-blocker	74 (67.3)	73 (66.4)	0.886
CCB	45 (40.9)	49 (44.6)	0.586
Nitrates	98 (89.1)	96 (87.3)	0.676
LMWH	101 (91.8)	102 (92.7)	0.801

Abbreviations: CCB, calcium channel blocker; FFR, fractional flow reserve; LMWH, low molecular weight heparin; MI, myocardial infarction; SD, standard deviation.

Table 2 Outcomes of patients in clinical therapy guided by FFR or angiography alone

Outcomes	FFR-guided groupM (n=110)	Angiography-guided group (n=110)	P-value
Adverse events
MACE	9 (8.2)	11 (10.0)	0.639
MACCE	10 (9.1)	13 (11.8)	0.509
Cardiovascular death	4 (3.6)	5 (4.5)	0.734
Nonfatal MI	5 (4.5)	7 (6.4)	0.553
Heart failure	4 (3.6)	5 (4.5)	0.734
Stroke	0 (0)	1 (0.9)	1.000
TIA	1 (0.9)	1 (0.9)	1.000
All-cause mortality	9 (8.2)	11 (10.0)	0.639
Contrast nephropathy	0 (0)	2 (1.8)	0.477
Major bleeding	2 (1.8)	3 (2.7)	1.000
Therapy strategies			0.039
Medical therapy	15 (13.6)	6 (5.5)
PCI	95 (86.4)	104 (94.5)

Notes: Data presented as n (%). MACE is defined as cardiovascular death, nonfatal MI, or unplanned hospitalization for heart failure; MACCE is defined as cardiovascular death, nonfatal MI, unplanned hospitalization for stroke, or TIA.

Abbreviations: FFR, fractional flow reserve; MACE, major adverse cardiac event; MACCE, major adverse cardiac and cerebral event; MI, myocardial infarction; PCI, percutaneous coronary intervention; TIA, transient ischemic attack.